Articles

Identification Of Pharmacological Active Compounds From Celery Leaves (Apium graveolens)

Author

Saraswathy S.*, Tan, S.C.and Shahimi M.

Proceeding

Simposium Kimia Analisis Kebangsaan Keenam, Selangor Malaysia.

Date

28/10/1992

Keyword

Celery leaves, Apium graveolens, pharmocological studies, bioactive compounds

Abstract

In preliminary in vivo studies, it was shown that sadri had the ability to reduce the blood pressure and heart rate. However, there were some difficulties in identification of pharmocologically active compounds in crude sample due to antagonistic or synergistic components. In this studies crude sadri samples were separated into 5 fractions namely fraction A, B, C, D and E. Pharmocological studies showed that fraction C was the most potent. It was observed that at a dose of 16.66 mg/kg it reduced the blood pressure by 55.0 + 2.1% and heart rate by 37.0 + 5.0%. At a dose of 33.3 mg/kg it has the potential to reduce blood pressure and heart rate even more, that is 69.0 + 5.5% and 48.0 + 3.1%. At the highest dose (66.66 mg/kg) blood pressure was reduced by 82.0 + 5.5% and heart rate by 48.0 + 6.2%. The results showed that a dose dependent effects on blood pressure and heart rate. Further studies done on the most potent fraction showed that pharmacological active components are highly charged and polar, phenolic, alkaloid anthraquinone glycoside or aglucan substances.  LD value  obtained for fraction C was 3.457 gm/kg body weight.