Articles

Cascarosides A and B.

Author

Fairbairn JW, Evans FJ, Phillipson JD

Date

9/1977

Journal

J Pharm Sci

Abstract

Electron-impact and field desorption mass spectrometry, together with NMR and circular dichroism spectroscopy, were used to confirm that cascarosides A and B are C-10 isomers of 8-O-(beta-D- glucopyranosyl)barbaloin. Several batches of cascarosides A and B were prepared and oxidatively hydrolyzed to aloe-emodin. The results are discussed in relation to the assay for cascara given in the European Pharmacopoeia, 1971.