Articles

Cerebrospinal fluid and blood thiamine concentrations in phenytoin- treated epileptics.

Author

Botez MI, Joyal C, Maag U, Bachevalier J

Date

2/1982

Journal

Can J Neurol Sci

Abstract

Thiamine and folate levels in blood and cerebrospinal fluid (CSF) were determined by microbiological assays in 23 control subjects and 11 phenytoin-treated epileptics. There was no significant difference between the two groups for serum and CSF folate levels. There was, however, a statistically significant difference between the groups for both whole blood thiamine and CSF thiamine levels. Epileptic patients being treated with phenytoin had lower values than control subjects.