Articles

Anti-inflammatory activity of benzopyrones that are inhibitors of cyclo- and lipo-oxygenase.

Author

Della Loggia R, Ragazzi E, Tubaro A

Date

12/1988

Journal

Pharmacol Res Commun

Abstract

The anti-inflammatory activity of three benzo-pyrones with prevalent lipooxigenase-inhibitory activity was studied using the Croton oil ear test in mice, in comparison with nordihydroguaieretic acid (NDGA) and indomethacin. Kaempferol, quercetin and NDGA possess a strong and prolonged anti-inflammatory effect, whereas the action of indomethacin appears relevant, but not long-lasting. In contrast the anti-inflammatory activity of esculetin is rather weak, but persistent.