Articles

Kun Bu

Laminariae seu Eckloniae Thallus, Japanese Sea Tangle

Dosage

5-15 g/dose for decoction, or proper quantity to make into pill or powder.

Chemical Composition

Alginic acid; Fucoidan; Fucose; Laminarin; b-1,3-glucan; Aminine; Glutamic acid; Aspartic acid; Proline; Alanine; Histidine; Tryptophane; Methionine; Mannitol; Taurine; Palmitic acid; Oleic acid; Linoleic acid; g-linolenic acid; Fucosterol; Cubenol; Hexanal; (E)-2-hexenal; (E)-2-hexenol; Hexanol; Xylene; 1-octen-3-ol; Butylbenzene; (E)-2-octenal; (E)-2-octenol; (E)-2-nonenal; a-terpineol; b-Cyclocitral; (E)-2-decenol; b-ionone; Pentadecane; Epicubenol; Myristic acid; w-phytol; Dibutylphthalide; Carotene; b-Homocyclocitral; Arachidonic acid; Eicosapentaenoic acid; Arsenical saccharide; Hexadecenoic acid; Octadecatetraenoic acid; (E, E)-2, 4-decadienal; (E, E)-2,4-heptadienal; (E, Z)-2, 6-nonadienal; (E, E)-2,4-octadiena; Vitamin B1, B2, C. (1) , (2) , (3) , (4)

Inorganic Chemicals

S, K, Mg, Ca, P, Fe, Mn, Mo, I, Al, phosphoric acid radical, carbonic acid radical, sulfuric acid radical.

Precautions

Patients suffering from spleen-stomach deficiency and coldness should exercise caution in using this herb.

Pharmacology

Counteracting arteriosclerosis and peroxidation

Studies show that Kun Bu can significantly increase the activity of lecithin cholesterol acyltransterase in rats with experimental hyperlipidemia, raise the level of high density lipoprotein cholesterol (HDL-C), especially that of HDL2-C, and lower the level of total cholesterol. It can reduce lipid superoxide, promote the elimination of cholesterol (thereby improving the lipid metabolism disorder), and strengthen the body’s function of counteracting lipid peroxidation. (5)

Inhibiting blood vessel generation and antineoplastic effects

Kun Bu polysaccharide sulfate inhibits the adhesion of alkaline fibroblast growth factor and the proliferation of fibroblast-dependant cells. It inhibits endothelial cells from forming tubular construction and inhibits allantochorion formation. It can also suppress the growth of RIF-1 tumors in rats. (6)

Effects on hyperlipoproteinemia

Studies show that Kun Bu can significantly reduce the levels of total cholesterol, b-lipoprotein, and triglyceride, raise the levels of HDL-C and HDL2-c, reduce relative blood viscosity, relative plasma viscosity, reduction viscosity and fibrinogen. But it does not affect hematocrit and erythrocyte deformation indexes. (7)

Relieving cough and counteracting asthma

Kun Bu extract is effective in relieving sulfur dioxide-induced cough in rats, or by electrostimulation-induced cough in cats. It also can prevent histamine-induced asthma in guinea pigs. (8)

Bacteriostatic activity

Kun Bu iodine can kill a number of bacteria and viruses. The extract is an effective germicide to 5 kinds of commonly encountered pathogenic microbes such as trichophyta rubra. (9)

Effects on the thyroid gland

Kun Bu can recover thyroid dysfunction due to iodine deficiency. It can be used to temporarily suppress the metabolic rate in hyperthyroidism and consequently relieve patients’ symptoms. (10)

References

  1. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Techonology Press; 1998.
  2. Wang Xue Zhao, et al. Southwestern Journal of Pharmacology. 1995;10(3):99-101.
  3. Hou Yu Li. Journal of Avant-garde Medicine. 1985;(1):21-23.
  4. Fan Xiao, et al. Journal of Marine Medicinal Materials. 1993;12(4):32-38.
  5. Huang Zhao Sheng, et al. China Journal of Ocean Medicinal Products. 1998;17(1):35-37.
  6. Xu Zhong Ping, et al. Journal of Chinese Materia Medica. 1999;30(7):551-553.
  7. Tang Zhao Li, et al. Journal of Integrated Medicine. 1989;9(4):223-225.
  8. Jiangsu New Medical College (ed). Dictionary of Chinese Medicines. Shanghai Science and Techonology Press; 1998.
  9. Kong Li Jun, et al. Journal of Dalian Medical College. Sep1994;16(3):212-213.
  10. Jiangsu New Medical College (ed). Dictionary of Chinese Medicines. Shanghai Science and Techonology Press; 1998.