Articles

A prospective study of the efficacy of Serenoa repens, tamsulosin, and Serenoa repens plus tamsulosin treatment for patients with benign prostate hyperplasia

Author

Hizli F, Uygur M. C.

Journal

International Urology Nephrology

Volume

39

Issue ID

3

Page

879-86

Date

2007

Keyword

Alternative medicine
Adult
Aged
Drug Therapy, Combination
Humans
Male
Middle Aged
*Phytotherapy
Plant Extracts/*therapeutic use
Prospective Studies
Prostatic Hyperplasia/*drug therapy
Receptors, Adrenergic, alpha-1/*antagonists & inhibitors
Serenoa
Sulfonamides/*therapeutic use
Treatment Outcome

Abstract

INTRODUCTION: Increasing attention has been focused on the use of phytotherapeutic agents to alleviate the symptoms of benign prostatic hyperplasia (BPH) in recent times. The best described and studied phytotherapeutic agent is Serenoa repens (SR). MATERIALS AND METHODS: This prospective study was  designed to have 3 arms including SR 320 mg per day (N = 20), Tamsulosin (TAM) 0.4 mg per day (N = 20) and SR + TAM (N = 20) to reveal the superiority or equivalence between these treatment regimens in BPH. RESULTS: The groups were not statistically different with regard to increase in maximal urinary flow rate (Q (max)) and decrease in International Prostate Symptom Score (I-PSS) (P > 0.05). No adverse effect was detected in SR therapy group. CONCLUSION: Treatment of  BPH by both SR and TAM seems to be effective alone. None of them had superiority to another and additionally, combined therapy (SR + TAM) does not provide extra benefits. Furthermore SR is a well-tolerated agent that can be used alternatively in the treatment of LUTS due to BPH.

Language

English