Articles

Antinociceptive and antiinflammatory activities of pine (Pinus densiflora) pollen extract

Author

Choi E. M.

Journal

Phytother Res

Volume

21

Issue ID

5

Page

471-5

Date

2007 May

Keyword

Alternative medicine
Analgesics/chemistry
Analgesics/isolation & purification
Analgesics/therapeutic use*
Animals
Anti-Inflammatory Agents/chemistry
Anti-Inflammatory Agents/isolation & purification
Anti-Inflammatory Agents/therapeutic use*
Arachidonic Acid
Carrageenan
Edema/chemically induced
Edema/drug therapy
Formaldehyde
Male
Mice
Mice, Inbred ICR
Pain/chemically induced
Pain/drug therapy
Pain Measurement
Phytotherapy*
Pinus/chemistry*
Plant Extracts/chemistry
Plant Extracts/isolation & purification
Plant Extracts/therapeutic use*
Pollen/chemistry

Abstract

The study aimed to evaluate the antinociceptive and antiinflammatory activity of  pine (Pinus densiflora) pollen in mice. The antinociceptive activity was determined using acetic acid-induced abdominal constriction and formalin-induced  licking, and the hot plate test. Antiinflammatory effects were evaluated using carrageenan- and formalin-induced paw edema, and arachidonic acid-induced ear edema in mice. The ethanol extract of pine pollen (100 and 200 mg/kg, p.o.) produced a significant inhibition of both phases of the formalin pain test in mice, a reduction in mouse writhing induced by acetic acid and an elevation of the pain threshold in the hot plate test in mice. The pine pollen extract also produced a significant inhibition of carrageenan- and formalin-induced paw edema  as well as arachidonic acid-induced ear edema in mice. The inhibitions were similar to those produced by aminopyrine and indomethacin, p.o. The different polyphenols found in pine pollen could account for the antinociceptive and antiinflammatory actions. The results obtained indicate that the extract possesses analgesic and antiinflammatory effects. Copyright 2007 John Wiley & Sons, Ltd.

Language

English