Articles

Comparative study on treatment of somnipathy in patients with hypertension by traditional Chinese medicine and by estazolam

Author

Li H. C., Yang Y. L., Ma M.

Journal

Chinese journal of integrated traditional and Western medicine

Volume

27

Issue ID

2

Page

123-6

Date

2007 February

Keyword

Alternative medicine
Adult
Aged
Aged, 80 and over
Anticonvulsants/therapeutic use
Blood Pressure/drug effects
Diagnosis, Differential
Drugs, Chinese Herbal/therapeutic use
Estazolam/therapeutic use*
Female
Humans
Hypertension/diagnosis
Hypertension/physiopathology
Hypertension/therapy*
Male
Medicine, Chinese Traditional*
Middle Aged
Phytotherapy
Sleep Initiation and Maintenance Disorders/diagnosis
Sleep Initiation and Maintenance Disorders/physiopathology
Sleep Initiation and Maintenance Disorders/therapy*

Abstract

OBJECTIVE: To study the efficacy of traditional Chinese medicine (TCM) in treating somnipathy in patients with hypertension, and to observe the change of blood pressure after sleep being improved.

METHODS: Two hundred and thirty-nine patients with hypertension accompanied somnipathy were randomly assigned to two groups, 123 patients in the treated group were treated with TCM according to syndrome differentiation, and 116 in the control group treated with Estazolam. Changes of blood pressure, scores of sleep dysfunction rating scale (SDRS), Hamilton anxiety rating scale (HAMA) and treatment emergent symptom scale (TESS) before and after treatment were observed.

RESULTS: TCM showed a significant effect on hypnagogic disturbance, and significantly reduced the scores of insomnia syndromes in early sleep stage, improve the quality of sleep, prolong the sleeping time to fulfill the physiological requirement, the total effective rate being 80.5% (99/123 cases), with the overall effect higher than that (66.4%, 77/116 cases) in the control group (P < 0.05). Along with the improving of sleep, blood pressure, both systolic and diastolic, reduced in both groups, but with the reduction in the treated group superior to that in the control group (P < 0.01), and the rate of reaching target BP (< 140/90 mmHg) in the former was also significantly higher than that in the latter (39.7%, 46/116 cases, P < 0.05). As compared with those in the control group, the occurence of adverse reaction, were less in the treated group (P < 0.05).

CONCLUSION: TCM has better efficacy in treating somnipathy of hypertension patients than Estazolam. And the improvement of somnipathy is favorable for improving the hypertensive condition of patient.

Language

Chinese