Curcuma heyneana Valeton & Zijp

Synonyms

No documentation

Vernacular Names

Malaysia Temu giring [1]
Indonesia Temu giring, temu reng (Java); Temu poh (Bali) [2]

General Information

Description

Curcuma heyneana is a member of the Zingiberaceae family. It is a herb with a lot of branched and elongated rhizomes which are medium in size and bright yellow on cross-section. The leaves are green, have long petiole with elliptical blades measuring 17.5-42 cm x 7.5-13 cm, leaf sheaths 22-35 cm long. The inflorescence appears within the leaves on a separate shoot, bracts pale green. The coma is purplish in colour. The corolla is whitish about 4 cm long, labellum about 16 mm x 16 mm, white with a dark yellow median band to yellow, other staminodes longitudinally folded with whitish to yellow colour, and the anther with short spurs. [2] [3] [4]

Plant Part Used

Rhizomes

Chemical Constituents

C. heyneana rhizomes has been reported to contain sesquiterpenes lactone (e.g. zedoarondiol), sesquiterpenes (e.g. curcumin; demethoxycurcumin; bis-demethoxycurcumin, and alpha-sitoserol), zerumbone, furanodienone, zederone, oxycurcumenol epoxide, curcumenol, isocurcumenol, and stigmasterol. [5] [6] [7]

Traditional Uses

C. heyneana has been used in some of the formulations documented in various Malay medicine manuscripts. The most common use of this plant is in slimming formulations either in the form of fresh juice, decoction or as poultice. Decoction of the rhizome is used to treat worm infestation. The rhizome in combination with leaves of Murraya paniculata and Lawsonia inermis in a decoction is used in the treatment of hypertension and cerebro-vascular accidents. The juice expressed from a combination of a number of herbs including the rhizome of C. heyneana is given in cases of dysentery. It also has been advocated in the treatment of cuts and wounds, to help reduce body odour and as a remedy for chicken pox. [3] [4] [8]

Pre-Clinical Data

Pharmacology

Anti-inflammatory activity

Zedoarondiol, a sesquiterpene lactone isolated from the rhizome of C. heyneana showed anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated macrophage cells of RAW264.7 and mouse peritoneum with the ability to inhibit inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokine expression by suppressing the phosphorylation of Ikappa B kinase and mitogen-activated protein kinases, with subsequent inactivation of nuclear factor-kappa B pathway. [5]

Cytotoxic activity

Curcumenol, oxycurcumenol epoxide and isocurcumenol isolated from C. heyneana showed moderate inhibitory activity against T-acute lymphoblastic leukaemia cells (CEM-SS) in cytotoxic assay with IC50 values of 11.9 μg/mL (oxycurcumenol epoxide), 12.6 μg/mL (curcumenol), and 13.3 μg/mL (isocurcumenol). [7]

Protein tyrosin phosphatase 1B inhibition

Methanol extract of C. heyneana (25 μg/ml) showed more than 70% inhibition against protein tyrosine phosphatase 1B (PTP1B) in the screening among 28 Indonesian medicinal plants for their PTP1B inhibition activity, thus could contribute to type II diabetes and/or obesity prevention. [9]

CYP3A4 and CYP2D6 inhibitory activity

Ethyl acetate soluble fraction of methanol extract of C. heyneana was found to have 67.0% inhibitory activity against human cytochrom P450 3A4 (CYP3A4) CYP3A4 using radiometric assay. [10]

Toxicities

No documentation

Teratogenic effects

No documentation

Clinical Data

Clinical Trials

No documentation

Adverse Effects in Human:

No documentation

Used in Certain Conditions

Pregnancy / Breastfeeding

No documentation

Age Limitations

Neonates / Adolescents

No documentation

Geriatrics

No documentation

Chronic Disease Conditions

No documentation

Interactions

Interactions with drugs

No documentation

Interactions with Other Herbs / Herbal Constituents

No documentation

Contraindications

Contraindications

No documentation

Case Reports

No documentation

References

  1. Jamal JA, Ghafar ZA, Husain K. Medicinal plants used for postnatal care in Malay traditional medicine in the Peninsular Malaysia. Pharmacognosy Journal. 2011;3(24):15-24
  2. Hariana HA., Tumbuhan Obat & Khasiatnya Volume 3. Jakarta: Penebar Swadaya, 2008: p. 125.
  3. Sodibyo BRAM, Alam sumber kesehatan: Manfaat dan kegunaan. Jakarta: Balai Pustaka, 1998; p. 364.
  4. Wardini TH, Prakoso B.. Curcuma heyneana Valeton & v. Zijp In: de Padua LS, Bunyapraphatsara N, Lemmens RHMJ, editors. Plant Resources of South-East Asia No. 12(1): Medicinal and poisonous plants 1. Leiden, Netherlands: Backhuys Publisher, 1999; p. 215.
  5. Cho W, Nam JW, Kang HJ, Windono T, Seo EK, Lee KT. Zedoarondiol isolated from the rhizoma of Curcuma heyneana is involved in the inhibition of iNOS, COX-2 and pro-inflammatory cytokines via the downregulation of NF-kappaB pathway in LPS-stimulated murine macrophages. Int Immunopharmacol. 2009;9(9):1049-57. Epub 2009 Apr 24.
  6. Bos R, Windono T, Woerdenbag HJ, Boersma YL, Koulman A, Kayser O. HPLC-photodiode array detection analysis of curcuminoids in Curcuma species indigenous to Indonesia. Phytochem Anal. 2007;18(2):118-22.
  7. Aspollah Sukari M, Wah TS, Saad SM, et al. Bioactive sesquiterpenes from Curcuma ochrorhiza and Curcuma heyneana. Nat Prod Res. 2010;24(9):838-45.
  8. Santoso HB. Ragam & khasiat tanaman obat. Jakarta: PT Agromedia Pustaka, 2008; p. 118-123.
  9. Saifudin A, Kadota S, Tezuka Y. Protein tyrosine phosphatase 1B inhibitory activity of Indonesian herbal medicines and constituents of Cinnamomum burmannii and Zingiber aromaticum. J Nat Med. 2013;67(2):264-270. Epub 2012 May 30
  10. Usia T, Iwata H, Hiratsuka A, Watabe T, Kadota S, Tezuka Y. CYP3A4 and CYP2D6 inhibitory activities of Indonesian medicinal plants. Phytomedicine. 2006;13(1-2):67-73. Epub 2005 Jun 29.