An observation of the percutaneous absorption of total alkaloids and terpenoid lactones of Tripterygium wilfordii

Author

Peng, D., Liu, Q., Zhao, Z., Huang, W., Qiu, J.

Publisher

Zhong Yao Cai

Edition

20/10

Date

10/1997

Keyword

Administration, Topical Alkaloids: *pharmacokinetics Animals Drugs, Chinese Herbal: administration & dosage: chemistry: *pharmacokinetics Female Humans Lactones: *pharmacokinetics Male Rats Rats, Wistar* Skin Absorption Spectrophotometry, Ultraviolet Terpenes: pharmacokinetics Time Factors Tripterygium: *chemistry

Abstract

The main ingredients of Tripterygium wilfordii are total alkaloids and terpenoid lactones. The authors studied the percutaneous absorption of these compounds on mice by means of ultravillet spectrophotometry. The results showed that these alksloids and lactones could pass through the skin of the mice. The rate of 12-hour percutaneous absorption was 13.40% for the former and 17.60% for the latter. After the application of Tripterygium wilfordii adhesive plaster to the human skin for 12 hours, the two ingredients were absorbed 17.34% and 22.13% respectively. This suggests that Tripterygium wilfordii can really be administered through the skin.