Antimalarial Activity of Cichorium intybus

Author

Faraz Mojab, Mehdi Nateghpour, Bahman Nickavara and Gholamreza Hakiminiaa

Proceeding

Traditional & Complementary Medicine Exhibition 2007 (TCME 2007), Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia

Date

17/7/2007

Keyword

antimalaria, Plasmodium bergei, Cichorium intybus

Abstract

Tropical infections are common place in some countries and most of their populations still rely on the use of plant extracts to combate the ravages of protozoa. In Iranian traditional medicine,Cichorium intybus(chicory) fam. Composite was used for relieve of fever. In this study we evaluate antimalarial activity of chicory againstPlasmodium bergheiinfections in mice (Peter’s method). The test procedure was based on suppression of parasitemia compared with that in controls. The mices inoculated intraprituanally withP. bergheion day 0. Oral doses of plant extracts micronised in normal saline have given 3h later. Same oral dose have given every 24h for further days. Tests have used six concentrations of extracts each using seven mices. Blood smears prepared and parasitemia determined. Chloroquine was used as a positive control. Doses 0.07 and 0.1 mg/kg were the most effective and provided 0 of parasitemia in 4th day. As above results, the extract of chicory is a good source of antimalarial agents and is supposing for further researches.