Cynodon Dactylon; An Ordinary Plant With Extraordinary Cardioprotective Effects

Author

Moslem Najafi, Hossein Nazemiyeh, Alireza Garjani, Hamed Ghavimi and Afshin Gharakhani

Proceeding

Traditional & Complementary Medicine Exhibition 2007 (TCME 2007), Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia

Date

17/7/2007

Keyword

Cynodon Dactylon, arrhythmias, isolated heart, rat

Abstract

Cynodon Dactylon(Cyn.Dac) has been used in the folk medicine of many countries for different purposes. To date, it is not reported any cardioprotective effects of the plant against cardiac arrhythmias. In the present study, effects of Cyn.Dac on ischemia-induced arrhythmias were investigated in isolated rat heart. The isolated hearts were divided into four groups (n=8-12 in each group) then subjected to 30min regional ischemia and perfused with hydroalcoholic extract of rhizomesfrom Cyn.Dac (50, 100 and 200μg/ml). Compared to the control group, the extract (50μg/ml) produced marked (p<0.01)reduction in the number and duration of ventricular tachycardia (VT). The total number of ventricular ectopic beats (VEBs) were reduced from 667±148 in the control to 56±22 by 50μg/ml (p<0.001) and 276±43 by 100μg/ml (p<0.05), respectively. Cyn.Dac (50μg/ml) also decreased incidence of VT from 100% (control) to 17% (p<0.01). The extract also produced potent positive inotropic effects in the heart (p<0.01 for all concentrations). The results showed protective effects of Cyn.Dac against ischemia-induced arrhythmias in isolated rat heart. Regarding the presence of steroidal saponins confirmed by phytochemical screening and the role of similar structures in inotropic agents, Cyn.Dac may probably act like digoxin. Anti­inflammatory and direct mechanism(s) may also involve.