Gastroprotective Effect of Orthosiphon Stamineus Standardized Extract on Ethanol-induced Gastropathy in Rats

Author

Mun Fei Yam, Mariam Ahmad, Mohd. Zaini Asmawi and Rusliza Basir

Proceeding

Traditional & Complementary Medicine Exhibition 2007 (TCME 2007),Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia

Date

17/7/2007

Keyword

Orthosiphon stamineus, gastroprotective, lipid peroxidation

Abstract

The gastroprotective effect of standardized extract ofOrthosiphon stamineus(SEOS) was studied using the absolute ethanol-induced ulcerogenesis in rat. Oral administration of SEOS (125, 250, 500 and 1000 mg/kg) was found to significantly increase the ulcer index (p<0.01, p<0.001, p<0.001 and p<0.001 respectively). The histological study on the section of the rat stomach also showed a marked improvement in the gastric mucosal damage in groups receiving SEOS. In order to further investigate the gastric protective mechanism of SEOS, mucus secretion and lipid peroxidation level (in vitro and in vivo) were estimated. SEOS exhibited dose-dependent stimulation of mucus secretion (r=0.718, p<0.001) and inhibition of lipid peroxidation in rat gastric mucosal homogenates (in vitro (r=0.819, p<0.05); in vivo (r=0.981, p<0.05)). It was concluded that the gastric protective mechanism of SEOS was partly due to its ability to inhibit lipid peroxidation and stimulate gastric mucus secretion.