Antimalarial Activity of Some Medicinal Plants from Iran

Author

Esmaeili Somayeh, Naghibi Farzaneh, Noor Rain Abdullah, Mosaddegh Mahmoud, Rohaya Chomel and Rosilawati Muhamad

Proceeding

Traditional & Complementary Medicine Exhibition 2007 (TCME 2007, Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia

Date

17/7/2007

Keyword

antimalaria, medicinal plants, screening

Abstract

Malaria is a major global public health problem and the alarming spread of drug resistance and limited number of effective drugs now available underline how important it is to discover new antimalarial compounds. History shows that plants have been an important source of medicines against malaria with two of the major drugs used in malaria treatment, quinine and more recently artemisinin both having derived from plants. In this study twenty plants were selected mainly on the basis of ethno botanical investigation and/ or antimicrobial activity. The methanol extracts were prepared and tested for theirin vitroactivity againstPlasmodium falciparumand assessed for any cytotoxicity against the normal cell line. In a first screening, fourteen extracts showed antiplasmodial activity. The IC50values of the most active extracts were determined as well as their selectivity towardsP. falciparumin comparison to their cythotoxic effects against the normal cell. Four plants showed better antiplasmodial activity (IC50ranging from 0.4-0.8 μg/ml) with a good selectivity. Further phytochemical investigations are in process in our laboratory.