Marine Invertebrate-Derived Fungi and Their Bioactive Compounds.

Author

NOR AINY MAHYUDIN, ANTHONY COLE, MURRAY MUNRO, JOHN BLUNT, NIC CUMMINGS, GERHARD LANG AND MAYA MITOVA

Proceeding

The 21st Annual Seminar of the Malaysian Natural Product Society.(Herbal Medicine:Natural Products S ciety), Palm Garden, Putrajaya Malaysia.

Date

22/11/2005

Keyword

Marine-derived fungi, effect of seawater, anticancer, cytotoxic metabolites

Abstract

The huge biological diversity of the marine environment offers exciting potential in the search for novel biologically active compounds. More than 17,000 new compounds have been described from marine organisms. Some of these, originating mainly from invertebrates, are of pharmacological importance, especially as anti-cancer and anti-inflammatory lead compounds. It has been postulated that the production of these metabolites may not be a function of the invertebrate, but that of the associated micro flora. In the case of fungi, there is no evidence of invertebrate colonization, however, isolation of obligate marine fungi and production of unique metabolites may indicate a more intimate association with the marine world than just as commensally organisms. Tissue and liquid portions of marine invertebrates have been sampled for fungi.  A selection of these marine isolates were compared with terrestrial isolates in both seawater and non-seawater media. Marine isolates shared a preference for saline conditions. Cytotoxicity and the nature of the bioactive compounds produced by these marine-derived fungi in liquid and solid media are discussed.