Aporphine Alkaloids from Litsea tomentosa Blume

Author

LIA D. JULIAWATY, MELISSA D. NOVIANTI, SANDRA R. A. KRISNA, YANA M. SYAH, EUIS H. HAKIM, LUKMAN MAKMUR, SJAMSUL A. ACHMAD, JALIFAH LATIP & LAILY BIN DIN

Proceeding

The 21st Annual Seminar of the Malaysian Natural Product Society.(Herbal Medicine:Natural Products S ciety), Palm Garden, Putrajaya Malaysia.

Date

22/11/2005

Keyword

Litsea tomentosa, aporphine alkaloids, (S)-predicentrine, (S)-boldine, (S)-laurolitsine, (S)-launobine

Abstract

Four aporphine alkaloids, (S)-predicentrine, (S)-boldine, (S)-laurolitsine and (S)-launobine  were obtained from the heartwood of Litsea tomentosa Blume. While from the stem bark only (S)-laurolitsine and (S)-launobine were isolated. Their structures were elucidated from spectral evidence compared with corresponding literature data. The cytotoxic activities of the isolated compounds were also examined against murine leukemia cells P388.