Resveratrol Tetramers from Dipterocarpus hasseltii: Cytotoxic Effect and Chemotaxonomic Significance

Author

MUHTADI, EUIS H. HAKIM, YANA M. SYAH, LIA D. JULIAWATY, SJAMSUL A. ACHMAD, IKRAM M. SAID, LAILY BIN DIN, JALIFAH LATIP

Proceeding

The 21st Annual Seminar of the Malaysian Natural Product Society.(Herbal Medicine:Natural Products S ciety), Palm Garden, Putrajaya Malaysia.

Date

22/11/2005

Keyword

Resveratrol tetramer, Dipterocarpus hasseltii, Dipterocarpaceae, Cytotoxic, Chemotaxonomy.

Abstract

Two resveratrol tetramers, (-)-vaticanol B and (-)-hopeaphenol, were isolated from the acetone extract of the bark of Dipterocarpus hasseltii (Dipterocarpaceae), together with the known resveratrol trimer, (-)-α-viniferin. The structures of these compounds were established based on spectroscopic evidence, UV, IR, 1H-NMR, 13C-NMR and determined by comparison with the standard compounds. The cytotoxic activities of these compounds were evaluated  against murine leukaemia P-388 cells. The IC50 values of the compounds were 42.2, 5.0 and 17.5 μg/ml, respectively. In addition, chemotaxonomic relationship between Dipterocarpus, Shorea and Vatica will also be briefly discussed.