Phytochemistry and Cytotoxic Properties of 3-Prenylflavone Derivatives from Artocarpus champedenSpreng

Author

YANA M.SHAH,EUIS. H. HAKIM, LIA D. JULIAWATY, LUKMAN MAKMUR & SJAMSUL A. ACHMAD

Proceeding

The 21st Annual Seminar of the Malaysian Natural Product Society.(Herbal Medicine:Natural Products S ciety), Palm Garden, Putrajaya Malaysia.

Date

22/11/2005

Keyword

Artocarpus champeden, 3-prenyflavone derivatives, cytotoxic properties, structure-activity relationship.

Abstract

Twenty one 3-prenylflavone derivatives have been isolated from an endemic Artocarpus species in Indonesia, A. champeden. These include 2’,4’-dioxygenated- and 2’,4’,6’-trioxygenatedflavanones, 2’,4’-dioxygenated flavone, 2’,4’-dioxygenated- and 2’,4’,5’-trioxygenated 3-prenylflavones, 2’,4’-dioxygenatedoxepinoflavones, 2’,4’-dioxygenated- and 2’,4’,5’-trioxygenated-pyranoflavones, dihydrobenzoxanthones, and furanodihydrobenzo-xanthones. Some of the flavonoids exhibited strong cytotoxicity against murine leukemia P-388 cell lines, suggesting that flavonoids derived from moraceous plants represent a plausible unexplored resource of novel antitumor leads. Structure-activity relationship of the cytotoxic effects of the flavonoids is discussed.