Synthesis and Characterization Luteolin Derivatives

Author

ADIANA MOHAMED ADIB, FAREDIAH AHMAD & MUHAMMAD SUM IDRIS

Proceeding

The 21st Annual Seminar of the Malaysian Natural Product Society.(Herbal Medicine:Natural Products S ciety), Palm Garden, Putrajaya Malaysia.

Date

22/11/2005

Keyword

Luteolin derivatives, polyhydroxyl flavone, oxidative cyclisation, chalcone, 3Â’,4Â’,5,7-tetramethoxyflavone.

Abstract

In the present study, several reaction steps have been carried out to synthesize the derivatives of luteolin, which is a polyhydroxyl flavone. The first step of the reaction was the methylation of 2,4,6-trihydroxyacetophenone with methyl iodide to afford 2-hydroxy-4,6-dimethoxyacetophenone. An aldol condensation of 2-hydroxy-4,6-dimethoxyacetophenone with 3,4-dimethoxybenzaldehyde yielded 3,4,4’,6’-tetramethoxychalcone. This was followed by the oxidative cyclisation of chalcone with iodine in dimethylsulfoxide to give 3’,4’,5,7-tetramethoxyflavone.