Cytotoxic Chalcones and Flavanones from the Tree Bark of Cryptocarya costata Bl.

Author

HANAPI USMAN, EUIS H. HAKIM, TJODI HARLIM,MUHAMMAD N. JALALUDDIN, YANA M. SYAH, SJAMSUL A. ACHMAD & HIROMITSU TAKAYAMA

Proceeding

The 21st Annual Seminar of the Malaysian Natural Product Society.(Herbal Medicine:Natural Products S ciety), Palm Garden, Putrajaya Malaysia.

Date

22/11/2005

Keyword

7-Hydroxy-5,6-dimethoxyflavanone, Cryptocarya costata, cytotoxic, murine leukemia P- 388 cells.

Abstract

A new flavanone, 7-hydroxy-5,6-dimethoxyflavanone (1), together with three other flavonoids, didymocarpin (2), 2’,4’-dihydroxy-5’,6’-dimethoxychalcone (3), and isodidymocarpin (4), had been isolated from the methanol extract of the tree bark of Cryptocarya costata. The structures of these compounds were determined based on spectral evidence, including UV, IR, 1-D and 2-D NMR, and mass spectra. Cytotoxic properties of compounds 1 - 4 were evaluated against murine leukemia P-388 cells. The chalcones 3 and 4 were found to have greater cytotoxicities with IC50 values of 5.7 and 11.1 µM, respectively.