Resveratrol Oligomers from Hopea dryobalanoides: Chemotaxonomy and Cytotoxic Properties

Author

SAHIDIN, EUIS H. HAKIM, LIA D. JULIAWATY, YANA M. SYAH, LAILY BIN DIN, JALIFAH LATIP, IKRAM M. SAID

Proceeding

The 21st Annual Seminar of the Malaysian Natural Product Society.(Herbal Medicine:Natural Products S ciety), Palm Garden, Putrajaya Malaysia.

Date

22/11/2005

Keyword

Resveratrol oligomers, Diptoindonesin D, Hopea dryobalanoides, chemotaxonomy, murine leukemia P-388 cells.

Abstract

Eight resveratrol oligomers (diptoindonesin D, parviflorol, (-)-balanocarpol, heimiol A , hopeafuran, (+)-α-viniferin, vaticanol B and (-)-hopeaphenol) had been isolated from the acetone extract of bark of Hopea dryobalanoides. The structures of these compounds were determined based on spectral evidence, inlcuding UV, IR, 1-D and 2-D NMR, and mass spectra. The presence of these compounds in this plant, as well as the oligomer resveratrol from other Hopea species, has a great significance on the relationship between Hopea and other genera of Dipterocarpaceae. The cytotoxic properties of the compounds were determined against murine leukemia P-388 cells, and  (-)-hopeaphenol was found to be the most active with IC50 5.7 µM. Structure-activity relationship of these compounds on their cytotoxicities was also discussed.