The Biological Activities Of Bio-Catalyzer a.p NO. 11 ( Bio-Normalizer)

Author

Gloria de Castro-Bernas1, Gemma M. Remo2, Russell Abrigo2, Milagrosa S. Cuadra2, Godofredo Urbano2, Librado A. Santiago3, James A. Osato4 and Akitane Mori3 , 1Research Center for the Natural Sciences, University of Santo Tomas, Espana, Manila, Philippines 1008, 2Fil. Sun-0 International, Inc., Makati, Metro Manila, Philippines, 3Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, Okayama 700, Japan, 4Sun-0 International, Inc., Gifu 500,

Proceeding

Trends in Traditional Medicine Research, Proceedings of the International Conference on the Use of Traditional Medicine & Other Natural Products in Health Care

Date

8/6/1993

Keyword

Bio-normalizer, free radical scavenger, lipid peroxidation, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), bacteriostatic, enteric microorganisms, genotoxic agents, micronuclei, polychromatic erythrocytes, dimethylnitrosamine, cyclophosphamide.

Abstract

Bio-catalyzer a.p No. 11 (Bio-normalizer), a fermented natural health food product was found to he a potent scavenger of hydroxyl radicals and has some ability to quench superoxide and DPPH radicals. In vitro studies showed that oral administration of bio-normalizer (1 g/kg body weight) inhibited significantly thiobarbituric acid reactive substances (TBARS) formation, an index of lipid peroxidation, in the FeCl3 - induced epileptic focus in rats. The hydroxyl radical scavenging components of bio-normalizer proved to be heat and acid resistant, and can be stored for two years at 4°C without lost of activity. Studies on the antimicrobial activity of bio-normalizer revealed that bio-normalizer is bacteriostatic against commonly encountered enteropathogenic microorganisms and bactericidal to the rarely isolated member of the Enterobacteriaceae (Erwinia sp.). Bio-normalizer has been found also to inhibit the chromosome-breaking effect of somatic cell genotoxic agents, like dimethylnitrosamine (DMN) and cyclophosphamide when administered intraperitoneally and orally to Swiss Webster mice.