Effects of Volatile of Nigella Sativa Seeds

Author

Mahmoud Aqel and Rola Shaheen, College of Medicine, University of Jordan Amman-Jordan

Proceeding

Trends in Traditional Medicine Research, Proceedings of the International Conference on the Use of Traditional Medicine & Other Natural Products in Health Care

Date

8/6/1993

Keyword

Nigella sativa, volatile oil, smooth muscles contractions, antidiabetic property, antimicrobial activities.

Abstract

The effects of the volatile oil extracted from Nigella sativa seeds on the contractions of smooth muscles and on the levels of glucose and insulin were investigated. The volatile oil of N. sativa seeds inhibited the spontaneous movement and the contractions of rabbit intestinal segments induced by high potassium (K+) solution and acetylcholine stimulations. Also, the volatile oil inhibited the contractions of guinea pig tracheal smooth muscle strips induced by high K+ solution and histamine stimulations and the contractions of rabbit tracheal smooth muscle strips induced by high K+ solution and acetylcholine stimulations. Furthermore, the volatile oil inhibited the contractions of rabbit aortic rings induced by high K+ solution and norepinephrine stimulations. Moreover, the volatile oil inhibited the spontaneous movement and oxytocin - induced contractions of rat and guinea pig uterine horns. The intraperitoneal administration of the volatile oil (50 mg/kg) to fasting normal and alloxan-diabetic rabbits produced significant hypoglycemic effect without altering the basal insulin levels. This volatile oil was found recently to possess antimicrobial activities against: Staph, aureus, Pseudomonas aegenozae, E. coli, Strep, pneumoniae, Enterococcus, B.H. streptococcus, Diphteroids and Candida albicans. These data suggest that the volatile oil of N. sativa seeds has antispasmodic, antihistaminic, anticholinergic, antihypertensive, antioxytoxic, antihyperglycemic, antibacterial and antifungal activities.