The hypotensive Activity Of alkaloids From Uncaria Plants

Author

Si Geh, M.L. Leong and *K.H. Lee, Department of Pharmacology, Faculty of Medicine and *Department of Chemistry, Faculty of Science, University of Malaya, 59100 Kuala Lumpur.

Proceeding

Trends in Traditional Medicine Research, Proceedings of the International Conference on the Use of Traditional Medicine & Other Natural Products in Health Care

Date

8/6/1993

Keyword

Malaysian Uncaria species, isorhynchophylline, rhynchophylline, anaesthetised normotensive rats, systemic arterial pressure, heart rate.

Abstract

Alkaloids from Uncaria species cf. gambir were studied in anaesthetised normotensive rats for effects on the cardiovascular system. Two purified alkaloids, isorhynchophylline and ryhnchophylline, were observed to produce a good fall in the systemic arterial pressure which was accompanied by marked and sustained bradycardia.