How 5-Hydroxytryptophan (5-HTP) interacts with Antidepressants

Interaction type: Interactions

Interaction rating: Potential/Theoritical

Based on Pharmacology: Studies report that 5-HTP may have additive effects to antidepressants. This may alter the effects of these medications and possibly the dose needed for treatment. Use with caution. (1)

These drugs include fluoxetine, fluvoxamine, paroxetine, sertraline, amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, trimipramine, maprotiline, mirtazapine, trazodone, bupropion, venlafaxine, nefazodone, citalopram, protriptyline, phenelzine, tranylcypromine, isocarboxazid


  1. View Abstract: Kahn RS, et al. L-5-hydroxytryptophan in the Treatment of Anxiety Disorders. J Affect Disord. Mar1985;8(2):197-200.