How 5-Hydroxytryptophan (5-HTP) interacts with St. John's wort

Interaction type: Interactions

Interaction rating: Potential/Theoritical

Based on Pharmacology: Studies report that 5-HTP may have additive effects to St. John's wort. This may alter the effects of this supplement and possibly the dose needed for treatment. Use with caution. (1)


  1. View Abstract: Kahn RS, et al. L-5-hydroxytryptophan in the Treatment of Anxiety Disorders. J Affect Disord. Mar1985;8(2):197-200.