How Calcium interacts with Tetracyclines

Interaction type: Interactions

Interaction rating: Proven

Tetracycline antibiotics chelate with calcium, which prevents its absorption. Supplementation with the affected nutrient may be necessary. (1)

These drugs include tetracycline, demeclocycline, doxycycline, minocycline, oxytetracycline

References

  1. View Abstract: Lambs L, et al. Metal Ion-tetracycline Interactions in Biological Fluids. Part 3. Formation of Mixed-metal Ternary Complexes of Tetracycline, Oxytetracycline, Doxycycline and Minocycline with Calcium and Magnesium, and Their Involvement in the Bioavailability of These Antibiotics in Blood Plasma. Agents Actions. Jun1984;14(5-6):743-50.