How Calcium interacts with Fluoroquinolone Antibiotics

Interaction type: Interactions

Interaction rating: Proven

Calcium is capable of inhibiting the absorption of orally administered fluoroquinolones. Therefore, calcium supplements and milk/dairy products should not be taken concurrently with this class of antibiotics. (1) (2)

These drugs include ciprofloxacin, norfloxacin, ofloxacin, levofloxacin, moxifloxacin, gatifloxacin, lomefloxacin, sparfloxacin, trovafloxacin, alatrofloxacin


  1. View Abstract: Marchbanks CR. Drug-drug interactions with fluoroquinolones. Pharmacotherapy. Mar1993;13(2 Pt 2):23S-28S.
  2. View Abstract: Sahai J, Healy DP, Stotka J, et al. The influence of chronic administration of calcium carbonate on the bioavailability of oral ciprofloxacin. Br J Clin Pharmacol. Mar1993;35(3):302-4.