Ban Xia

Rhizoma Pinelliae, Pinellia Tuber

Dosage

Orally used, the decoction of the herb, 3-9 g, is administered.

Toxicity

The maximal tolerance dosage of Ban Xia decoction was 25g/kg (oral feeding or abdominal injection). (1)

Chemical Composition

Anethole; Benzaldehyde; 1,5-pentadiol; 3-methyleicosane; 2-methylpyrazine; Citral; 1-octene; b-elemene; 2-undecanone; 9-heptadecanol; Eihylpalmitate; Pentaldehyde oxime; b-sitosterol; Aspartic acid; Hexadecylendioic acid; Butyl-ethylene ether; Adenosine XXVII; Pedatisectine D, XXX; Pedatisectine E,XXXI; a-and b-aminobutyric acid; Methyl-2-chloroproper noate; 3-acetoamino-5-methylisooxazole; L-prolyl-L-alanineanhydride XXV; 3-acetamino-2-piperidone XXVI; L-phenylalanyl-L-serylanhydride XXVIII; L-tyrosyl-L-alanineanhydride XXIX. (2) , (3) , (4) , (5) , (6)

Inorganic Chemicals

Ca, K, Na, Fe, Al, Mg, Mn, P

Precautions

Ban Xia has strong irritating effects on the gastric mucosa. (7)

Pharmacology

Lowering blood lipid level

Experiments show that Ban Xia can prevent or postpone the development of dietary hyperlipidemia in rats, significantly lowering the subjects’ serum total cholesterol and LDL-C levels. (8)

Inhibiting tumor cell growth

Ginger-processed Ban Xia is found to have a rather pronounced inhibitory effect on the growth of tumor cell strain K562. (9)

Effects on the cardiovascular system

Experiments show that alcohol-based precipitation of Ban Xia water decoction can increase the volume of coronary blood flow in mice isolated hearts. (10)

Analgesic and anti-ulcer effects

Fed to mice at the dosages of 5g/kg and 15g/kg, 75 alcohol-based extract of alum-processed Ban Xia can significantly lengthen the incubation period for heat-induced pain reaction, and decrease of the number of acetic acid-induced body-twistings, indicating that it has a significant analgesic effect. The same treatment can also significantly inhibit the development of hydrochloric acid and indolmycin-alchohol-induced ulcers in mice, and significantly prolong the experimental thrombus time in rats. (11)

Anti-diarrhea and anti-inflammatory effects

Administered to mice by gastric perfusion at the dosages of 5g/kg and 15g/kg, 75% alcohol-based extract of Ban Xia can counteract castor oil and senna leaf-induced diarrhea. The same treatment can significantly inhibit acetic acid-induced increase in mice’s peritoneal capillary permeability, and significantly ameliorate dimethylbenzene-induced ear swelling in mice. (12)

Antitussive and antiemetic effects

Administered to mice in the dose of 2g/kg, the water decoction of Ban Xia can prolong the cough incubation period and reduce the number of coughs. The same treatment has an antiemetic effect on apomorphine-induced vomiting in cats. (13)

References

  1. Gui Chang Qing, et al. Journal of Pharmacology and Clinical Application of TCM. 1998;14(4):27-28.
  2. Wang Rui, et al. China Journal of Pharmacy. 1995;30(8):457-459.
  3. Wu Hao, et al. China Journal of Chinese Medicine. 1995;20(11):662-664.
  4. Ji Wen Lan, et al. Journal of Shizhen Medicinal Material Research. 1997;8(6):554.
  5. Wu Hao, et al. Journal of Nanjin University of TCM. 1999;15(5):287-289.
  6. Qin Wen Juan, et al. Journal of Chinese Materia Medica. 1995;26(1):3-6.
  7. Chen Lin Yun, et al. Journal of Yunnan College of TCM. 1997;20(4):17-19.
  8. Hong Xing Qiu, et al. Journal of Zhejiang College of TCM. 1995;19(2):28-29.
  9. Wu Hao, et al. Journal of Chinese Patented Medicine. 1996;18(5):20-22.
  10. Liu Shou Yi, et al. Liaoning Journal of Traditional Chinese Medicine. 1997;24(12):566.
  11. Shen Ya Qin, et al. China Journal of Biochemical Products. 1998;19(3):141-143.
  12. Shen Ya Qin, et al. Journal of Pharmacology and Clinical Application of TCM. 1998;14(2):29-31.
  13. Gui Chang Qing, et al. Journal of Pharmacology and Clinical Application of TCM. 1998;14(4):27-28.