Fang Feng

Saposhnikoviae Radix, Siler

Dosage

5~10g, decocted in water, or processed into boluses or powder for oral administration.

Toxicity

LD50 (mice): 30.046 ± 0.077g/kg (intraperitoneal injection/herb decoction); 21.38 ± 25.4g/kg (gastric infusion/herb decoction); 8.05 ± 1.6g/kg (intraperitoneal injection/water-based extract). (1)

Chemical Composition

Chromones; Ledebouliellol; Hamaudol; Cimifugin; Bergapten; Psoralen; Imperatorin; Phellopterin; Deltoin; Xanthotoxin; Anomalin; Scopoletin; Marmesin; Poly-acetylenes; Panaxynol; Falcarindiol; Octanal; b-bisabolene; Nonanal; 7 –octen –4 –ol; Hexanal; Cuparene; b- eudesmol; b-sitosterol; D – mannitol; Vanillic acid; Saposhnikovan A, C; 3’ –0 –angeloyhamaudol; 3’ – 0-acetylhamaudol; Sec-0-glucosylhamaudol; 5-0-methylvisamminol; Prim-0-glucosylcimifugin; b- sitosterol –b- D – glucoside; 4’-0-glucosyl-5-0-methylvisamminol; (8E)-heptadeca-1, 8 –dien –4, 6 –diyn –3, 10 –diol. (2)

Precautions

Patients with convulsion due to blood deficiency and those with hyperactivity of fire owing to yin-deficiency should use this herb with caution.

Pharmacology

Effects on blood rheology

Administered by intramuscular injection daily at the dosage of 5.6g/kg for ten days, n-butyl alcohol-based extract of Fang Feng can lower both the high and low shearing specific viscosity of total blood, plasma viscosity, fibrinogen content, hematocrit and total blood reduced viscosity but has no effect on blood sedimentation (BS), K value of BS equation, maximal platelet aggregation rate, and one-minute depolymerization rate. This suggests that n-butyl alcohol-based extract of Fang Feng can promote blood circulation and remove blood stasis. (3)

Antineoplastic effect

Experiments show that administered to mice, Fang Feng polysaccharide has the following effects: 1) inhibiting S180 growth, with a solid tumor-inhibiting rate of 52.92%; 2) notably raising the phagocytic activity of intraperitoneal macrophages (Mo) of S180 tumor immune mice (P

References

  1. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Technology Press; 1998.
  2. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Technology Press; 1998.
  3. Zhu Hui Jing, et al. Journal of Chinese Materia Medica. 1998;29(12):812-814.