Ge Gen

Puerariae Radix, Pueraria

Dosage

Decoction: 10-15g.

Toxicity

LD50 (mice/IV): 2.1 ( 0.2g/kg (Ge Gen solution); 1/6 ( 0.06g/kg (total progesterone); 738mg/kg (puerarin). (1) It is unlikely that use of Ge Gen for an extensive period of time would accumulate toxicity. (2)

Chemical Composition

Daidzein; Daidzin; Puerarin; 4'-methoxypuerarin; Genistein; Formononetin; Puerarol; Pueroside A, B; Lupenone; (-sitosterol; Docosanoic acid; Tetracosanoic acid; Allantoin; 6,7-dimethoxycoumarin; 5-methylhydantoin; Sophbradiol; Cantoniensistriol; Soyasapogenol A, B; Kudzusapogenol C, A; Puerarinxyloside, PG-2; Daidzein-r',7-diglucoside; Formononetin-7-glucoside; Glycerol-1-monotetracosanoate; 4'-O-glucosylpuerarin, PG-6; 3'-methoxypuerarin, PG-3; 3'-hydroxypuerarin, PG-1; (-sitosteryl-(-D-glucoside; Genistein-8-C-apiosyl(1→6)-glucoside; Daidzein-7-(6-O-malonyl)-glucoside; Daidzein-8-C-apiosyl(1→6)-glucoside; Dudzusapogenol B methyl ester. (3) , (4) , (5) , (6)

Pharmacology

Regulating the function of the heart

Administered by IV injection to dogs under anesthesia, puerarin (at the dosage of 20mg/kg) or Ge Gen total progesterone (at the dosage of 30mg/kg) can decrease the heartbeat, output of the heart, and the myocardial oxygen consumption. (7)

Counteracting myocardial ischemia

Experiments show that administered by IV injection to dogs with myocardial ischemia induced by IV-injecting pituitrin, Ge Gen total progesterone (at the dosage of 20-30mg/kg) can stop coronary blood vessel spasm, and increase coronary blood flow. (8)

Dilating blood vessels

Administered to dogs under anesthesia, puerarin (20mg/kg by IV injection) or Ge Gen total progesterone (20mg/kg by IV injection or 1-2mg/kg by intra-arterial injection) can dilate the blood vessels, decrease resistance, and increase blood flow. (9)

Lowering blood pressure

Administered by abdominal injection to spontaneously hypertensive rats, puerarin can lower the blood pressure, and decrease plasma renin activity. (10)

Anti-arrhythmia effect

Oral feeding solid dispersion of daidzein (SDD, 300mg/kg) to dogs can counteract barium chloride-induced arrhythmia, and prolong the duration of sinus rhythm. (11)

Lowering blood sugar

Oral feeding rabbits with Ge Gen water decoction can slightly lower their blood sugar level. Fed to mice of high blood sugar induced by alloxan at the dosage of 500mg/kg for 4-5 days, however, puerarin can lower the mice's blood sugar level. (12)

Lowering blood fat

Several active components of Ge Gen, including daidzein, formononetin, and genistein, have an inhibitory effect on blood fat. (13)

Anti-pyretic effect

Fed (2g/kg) to rabbits of typhoparatyphoid vaccine-induced fever, the water decoction of Ge Gen has a slight anti-pyretic effect. Ge Gen infusion, however, has a significant and lasting anti-pyretic effect. (14)

Anti-neoplastic effect

At the concentration of 14-22mg/ml, S86019, an active component of Ge Gen, has a time- and concentration-dependent inhibitory effect on HL-60. (15)

References

  1. Modern TCM Pharmacology. Tianjin: Science and Technology Press; 1997.
  2. Weng Hong Bo, et al. Journal of Shengyang University of Pharmacy. 1999;16(1):63-64.
  3. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Technology Press; 1998.
  4. Zhang Zun Ting, et al. China Journal of Pharmacy. 1999;34(5):301-302.
  5. Li Shi Sheng, et al. Journal of Chinese Materia Medica. 1999;30(6):416-417.
  6. Li Shi Sheng, et al. Journal of Natural Products Research and Development. 1999;11(1):31-33.
  7. Modern TCM Pharmacology. Tianjin: Science and Technology Press; 1997.
  8. Modern TCM Pharmacology. Tianjin: Science and Technology Press; 1997.
  9. Modern TCM Pharmacology. Tianjin: Science and Technology Press; 1997.
  10. Modern TCM Pharmacology. Tianjin: Science and Technology Press; 1997.
  11. Modern TCM Pharmacology. Tianjin: Science and Technology Press; 1997.
  12. Modern TCM Pharmacology. Tianjin: Science and Technology Press; 1997.
  13. Modern TCM Pharmacology. Tianjin: Science and Technology Press; 1997.
  14. Modern TCM Pharmacology. Tianjin: Science and Technology Press; 1997.
  15. Modern TCM Pharmacology. Tianjin: Science and Technology Press; 1997.