Huang Qin

Scutellariae Radix, Scutellaria

Dosage

Decoction 3~9g.

Chemical Composition

Baicalein; Wogonin; Groxylin-A; Chrysin; Oenaxin II; Viscidulin-I; (-sitosterol; Campesterol; Stigmasterol; Baicalin; Wogonoside; Oroxylin oroxylin A; 7-methoxybaicalein; SkullcapflavoneI; Dihydrooroxylin A; Norwogonin; Dihydrobaicalin; Eriodictyol; Rivularin; Viscidulin I, II, III; Tenaxin II; Wogonin-5-(-D-glucoside; 5,7,2'-trihydroxyflavone; 5-hydroxy-7,8-dimethoxyflavone; 2',3,5,6',7-pentahydroxyflavanone; Baicalein-7-O-(-D-glucopyranoside; 5,7,2',trihydroxy-8-methoxyflavone; Neobaicalein skullcapflavone II; 3,5,7,2',6'-pentahydroxyflavone; 2',5,8-trihydroxy-7-methoxyflavone; 2',5,8-trihydroxy-6,7-dimethoxyflavone; 4',5,7-trihydroxy-6-methoxyflavanone; 5,8-dihydroxy-6,7-dimethoxyflavone; 5,7,4'-trihydroxy-8-methoxyflavone; 5,2'-dihydroxy-6,7,8-trimethoxyflavone; 5,2',6'-trihydroxy-7,8-dimethoxyflavone; 5,2',5'-trihydroxy-6,7,8-trimethoxyflavone; Viscidulin III-2'-O-(-D-glucopyranoside; 5,7,2'-trihydroxy-8,6'-dimethoxyflavone; (2S)-7,2',6'-trihydroxy-5 -methoxyflavanone 5,7,2',5'-tetrahydroxy-8,6'-dimethoxyflavone; Chrysin-6-C-(-D-glucoside-8-C-(-L-arabinoside; Chrysin-6-C-(-L-arabinoside-8-C-(-D-glucoside; Oroxylin A-7-O-glucuronide,5,7,2'-trihydroxy-6-methoxyflavone; 5,7,2'-trihydroxy -6'-methoxyflavone, 5,7,2',3'-tetrahydroxyflavone; (2(2S)-2',5,6',7-tetrahydroxyflavanon,5,7, 2',6'-tetrahydroxyflavone; 2,6,2',4'-tetrahydroxy- 6'-methoxychalcone,5,7,2',5'-tetrahydroxyflavone; 2-(3-hydroxy-4-methoxyphenyl)eihyl-1-O-(-L-rhamnosyl(1ยกรบ3)-(-D-(4-feruloyl)glucoside. (1) , (2) , (3) , (4) , (5)

Inorganic Chemicals

Mg, Cr, Ni, Fe, K, Mn, Co, Pb, Zn, Mo.

Precautions

Reported adverse effects include allergic reactions and rashes. (6) , (7)

Pharmacology

Removing oxygen-free radicals

Huang Qin is among a number of Chinese herbs that can remove oxygen-free radicals. (8)

Anti-anaphylactic effects

Whether used alone or in combination with other herbs in a formula, Huang Qin can significantly inhibit histamine-induced increase in capillary permeability. (9)

Effects on liver cells

Isolated from the ethyl acetate-based extract of Huang Qin crystals I, II, III, and IV. The first three all have a significant liver-protective effect, while the last directly inhibits enzyme activity. (10)

Antineoplastic effects

Huang Qi can significantly inhibit the growth of AGZY-83 cells. Huang Qin's inhibitory effect on tumor cells, however, appears to be selective. (11)

Lowering blood pressure

Both the stem and the leaves of Huang Qi can significantly lower blood pressure. (12) By blocking voltage-dependent Ca-channels and receptor-controlled Ca-channels on the cytomembrane of smooth muscles, baicalin can inhibit the increase in Ca+21 in cells. (13)

Antipyretic effects

Experiments on mice show that two hours after being treated with Huang Qin, the temperature and the neurohypotensor hormone level are significantly lower (P

Anti-hypoxic effects

Experiments show that administered to mice by abdominal injection (0.1g/10g), water-based extract of Huang Qi can significantly increase the subjects' endurance against hypoxia (by as much as 133%), and lengthen their survival time from myocardial hypoxia (by as much as 114%). (14)

Antioxydation effects

Administered to mice by gastric infusion, Huang Qin total flavone can increase the activity of GSH-Px in the subjects' liver and brain tissues, and significantly reduce the content of LPO. (15)

Counteracting myocardial ischemia

Oral administration of Huang Qin total flavone (100mg/kg-1, 500ng/kg-1, 25mg/kg-1) can significantly lengthen mice's survival time from oxygen deficiency under ordinary pressure. It can counteract venous posterior pituitary hormone-induced myocardial ischemia in rats. It can also increase the flow of in-vitro coronary artery of guinea-pigs. (16) Administered by gastric infusion, it can counteract experimental arrhythmia in various animals. (17)

Antibacterial effects

Huang Qin can inhibit Serratia marcescens, hydrophilic monad and Staphylococcus aureus. (18) It has a very significant inhibitory effect on pyloric spirillum. (19)

Anti-inflammatory effects

The total flavone, oral administered, Huang Qin total flavone can inhibit dimethylbenzene-induced tumefaction in mice's ears and formaldehyde-induced tumefaction in rats' toes. It can also relieve dried yeast-induced fever in rats. (20)

Anti-mutagenic effects

Based on the observation that alcohol-based extract of Huang Qin inhibits aflatoxin B1-induced reverse mutation on TA98, it is considered that Huang Qin has an inhibitory effect on certain mutagens. (21)

Enhancing cellular immunity

Research shows that Huang Qin promotes the production of IL2, selectively enhances cellular immune functions in the body's immune response. But it has no significant effect on humoral immunity. (22)

Effects on galactose catract and correlative enzyme activity

Research indicates that Huang Qin can not only postpone the occurrence of galactose cataract, it also has a therapeutic effect for it. (23) Moreover, it can inhibit or correct the abnormal changes in enzyme activity due to galactose cataract. (24)

References

  1. Liu Mei Lan, et al. Journal of Chinese Materia Medica. 1988;19(2):50-52.
  2. Yang De Po, et al. Journal of New Chinese Medicine and Clinical Pharmacology. 1999;10(4):234-236.
  3. Li Zhong Rong, et al. Journal of Research and Development of Natural Resources. 1999;11(2):8-11.
  4. Yuan Bai Yong, et al. Journal of Trace Elements and Health Research. 1998;15(4):40-42.
  5. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Techonology Press; 1998.
  6. Wang Zhi Dao. Journal of Traditional Chinese Medicine Research. 1993;(1):13.
  7. Chen Rong Hua, et al. Jiangxi Journal of TCM. 1982;(1):32.
  8. Luo Pei Zhuo, et al. Guangxi Journal of Traditional Chinese Medicine. 1995;18(5):51-52.
  9. Huang Shu Ying, et al. Journal of Pharmacology and Clinical Application of TCM. 1996;12(3):28-29.
  10. Wang Li Ming, et al. Journal of Zhejiang University of TCM. 1996;25(6):241-244.
  11. Ling Hong, et al. Journal of Traditional Chinese Medicine. 1998;26(2):48-49.
  12. Tong Ji Ming, et al. Journal of Popular Medicine of Chinese Ethnic Minorities. 1995;(2):24-28.
  13. Hei Ai Lian, et al. Journal of Pharmacology and Clinical Application of TCM. 1998;14(4):6-8.
  14. Liu Xiao Juan, et al. Journal of Jingzhou Medical College. 1999;20(3):16-18.
  15. Li Su Ting, et al. Journal of Chende Medical College. 1999;16(4):306-308.
  16. Tong Ji Ming, et al. Journal of Chende Medical College. 1998;15(4):266-268.
  17. Tong Ji Ming, et al. Journal of Chende Medical College. 1999;16(4):311-314.
  18. Wang Ya Ping, et al. Shanghai Journal of Medical Inspection. 1999;14(4):206-207.
  19. Cao Zhi Sheng, et al. Strait Journal of Pharmacology. 1999;11(3):53-54.
  20. Tong Ji Ming, et al. Journal of Popular Medicine of Chinese Ethnic Minorities. 1999;(5):287-288.
  21. Cao Qun Li, et al. Journal of Traditional Chinese Medicine Material. 1991;14(3):42-44.
  22. Pan Ju Fen, et al. Tianjin Journal of Medicine. 1991;19(8):468-470.
  23. Yang Tao, et al. Journal of Beijing Medical University. 1991;23(2):97-99.
  24. Yang Tao, et al. Journal of Biochemistry. 1991;7(6):731-736.