Ji Xue Teng

Caulis Spatholobi, Milettia

Dosage

9-15g.

Toxicity

In an experiment wherein two dogs were administered by IV alcohol-based extract of Ji Xue Teng at the dosage of 2g/kg, both dogs died quickly, indicating that the herb has a certain level of toxicity. Substituting the injection with one mixed with Dan Shen, however, injecting the same amount of Ji Xue Teng had a fatality rate only one fifth of that of the original experiment, indicating that Dan Shen can significantly lower Ji Xue Teng's toxicity. (1)

Chemical Composition

Friedelan-3b-ol; Daucosterol; b-sitosterol; 7-oxo-b-sitosterol; Formonoetin; Ononin; Prunetin; Afrormosin; Daidzein; Epicatechin; 3,7-dihydroxy-6-methoxy-dihydroflavonol; Isoliquiritigenin; 2', 4', 3, 4-tetrahydroxy chalcone; Licochalcone A; Medicagol; Protocatechuic acid; 9-methoxycoumestrol Cajanin; Stigmast-5-ene-3b, 7a-diol; 5a-stigmastane-3b, 6a-diol. (2) , (3) , (4)

Pharmacology

Inhibition of blood platelet aggregation

Ji Xue Teng has an inhibitory effect on adenosine diphosphate-induced blood platelet aggregation in hamsters. (5)

Anti-fertility effects

Administered by oral feeding or abdominal injection to mice in early-stage pregnancy, Ji Xue Teng extract is moderately effective for inducing abortion. (6)

Regulating lipoprotein

Ji Xue Teng can raise the HDL2-C/HDL3-C ratio. (7)

Anti-viral effects

Experiments show that Ji Xue Teng extract has an inhibitory effect on herpes virus I (simplex). (8)

Effects on pyogenic cholangitis

In experiments using Ji Xue Teng to treat pyogenic cholangitis, the herb is found to decrease blood viscosity, reduce red cell aggregation, improve microcirculation, and lessen pathological damages to the liver and the kidney, thus lowering the fatality rate of the experiment subjects. (9)

Effects on aplastic anemia

In experiments designed to study the pathological effect of a Ji Xue Teng formula on patients of aplastic anemia, researchers have analyzed changes in the bone marrow before and after the treatment, and found that the formula improves bone marrow microcirculation. (10)

Preventing hematogenus metastasis

Research shows that Ji Xue Teng not only inhibits tumor cell blood platelet aggregation (p

Regulating immunity

Ji Xue Teng has a moderate inhibitory effect on cellular immunity (i.e., T-lymphocyte blastogenesis, and interleukin-2 activity); and to some extent, it affects delayed allergic reaction. (11) , (12)

Reducing side effects of chemotherapy

Ji Xue Teng has an inhibitory effect on cyclophosphamide-induced increase in polychromatic erythrocyte micronucleus rate, and on cyclophosphamide-induced decrease in white and red blood cell counts and in hemoglobin in the peripheral blood. (13)

Anti-neoplastic effect

Ji Xue Teng can increase LAK cell activity in mice (P

Effects on the hemopoietic system

Both chemotherapy and radiation therapy tend to cause anemia in mice, decreasing their white blood cell count, bone marrow nucleated cell count, and granulocyte division index, and Ji Xue Teng is shown to be able to counteract the decrease. (14) , (15)

References

  1. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Techonology Press; 1998.
  2. Lin Mao, et al. Journal of Chinese Materia Medica. 1989;20(2):53-56.
  3. Wang Rui, et al. Journal of Chinese Materia Medica. 1990;21(9):389-91.
  4. Li Jin, et al. China Journal of Pharmacy. 1999;34(10):686.
  5. Le Zhao Sheng, et al. Traditional Chinese Medicine Bulletin. 1985;10(1)44-45.
  6. Zhou Chang Jian, et al. Fujian Journal of Chinese Medicine. 1988;19(4):45-47.
  7. Wang Wei, et al. China Journal of Chinese Medicine. 1991;16(5):299-301, 320.
  8. Meng Zheng Mu, et al. Journal of University of Pharmacology of China. 1995;26(1):33-36.
  9. Dou Jian, et al. China Journal of Integrated External Medicine. 1995;1(6):363-366.
  10. Su Er Yun, et al. China Journal of Practical Internal Medicine. 1996;16(9):539-540.
  11. Yang Feng, et al. China Journal of Experimental Clinical Immunology. 1997;9(1):49-52.
  12. Xu Qiang, et al. Journal of Pharmacology and Clinical Application of TCM. 1993;9(4):30-33.
  13. Bo Xin, et al. Journal of Science and Technology of TCM. 1997;4(3):153-154, 175.
  14. Chen Yi Hong, et al. China Journal of Pharmacy. 1999;34(5):305-307.
  15. Liu Ping, et al. Journal of Pharmacology and Clinical Application of TCM. 1998;14(3)25-26.