Jie Geng

Platycodi Radix, Platycodon Root

Dosage

3-9g.

Toxicity

LD50 (mice/oral feeding/herb decoction): 24g/kg; LD50 (abdominal injection/platycodin): 22.3mg/kg (mice), 14.1mg/kg (rats).

Chemical Composition

Platycodin A, C, D, D2, D3; Deapioplatycodin D, D3; 2"-O-acetylplatycodin D2; 3"-O-actylplatycodin D2; Polygalacin D, D2; 2"-O-acetylpolygalacin D, D2; 3"-O-acetylpolygalacin D, D2; Methyl platyconater-A; Methyl 2-O-methylplatyconate-A; Platyconic acid-A lactone; Platycodigenin; Polygalacic acid; Platycogenic acid A, B, C; Prosaponin; Betulin; (-spinasterol; (-spinasteryl-(-D-glucoside; (Methyl-3-O-(-D-glucopyranosyl polygalacate; (Methyl 3-O-(-D-laminaribiosyl polygalacate; (3-O-(-D-glucopyranosyl platycodigenin methylester (3-O-(-D- laminaribiosyl platycodigenin methylester; (3-O-(-gentiobiosyl platycodigenin methylester; (3-O-(-D-glucopyranosyl platycodigenin A lactone methylester; (Dimethyl-3-O-(-D-glucopyranosyl platycogenate A (Dimethyl-2-O-methyl-3-O-(-D-glucopyranosyl platycogenate A. (1) , (2)

Precautions

Reported adverse reactions to Jie Geng include hypotension, vomiting, and allergic reactions. (3) , (4) , (5)

Pharmacology

Dispelling phlegm

Administered to guinea-pigs, Jie Geng infusion can raise blood pressure, increase heartbeat amplitude, weaken breathing, and increase saliva secretion. It can also increase tracheal secretion, with the ED50 being 1000ng/ml. (6) , (7) , (8)

Anti-bechic effect

Administered to rats by abdominal injection, Jie Geng extract has a 60% effective rate in arresting cough. (9) , (10) , (11)

Analgesic effect

Oral feeding platycodin to mice can prolong their pain latency.

Sedative effect

Oral feeding platycodin to mice can induce sleep. (12)

Anti-pyretic effect

Platycodin counteracts temperature rise in rats. (13) , (14)

Anti-inflammatory effect

Jie Geng promotes the secretion of corticosterone in rats, and thereby achieves an anti-inflammatory effect. (15) , (16) , (17)

Inhibiting ulceration

Jie Geng can prevent stress-induced ulcers, and inhibit ulceration in rats due to pyloric ligation. (18)

Central inhibitory effect

Oral feeding platycodin to mice inhibits their spontaneous activities. (19)

References

  1. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Technology Press; 1998.
  2. Gao Ya Qin, et al. Journal of Chinese Materia Medica. 1985;16(8)10.
  3. Zhou De Ping. Traditional Chinese Medicine Bulletin. 1988;13(1):51.
  4. Hu Zi Shui. Shandong Journal of TCM. 1995;14(5):224-226.
  5. Yang Guang Li. Journal of TCM Research. 1996;(4):53.
  6. Li Yin Fang (translator). Foreign Medicine, vol. of TCM. 1984;6(1):15-18.
  7. Zhang Shu Chen, et al. Journal of Chinese Patent Medicine Research. 1984;(2):37.
  8. Zhou Wen Zheng, et al. Pharmacy Bulletin. 1979;14(5):202-203.
  9. Li Yin Fang (translator). Foreign Medicine, vol. of TCM. 1984;6(1):15-18.
  10. Zhang Shu Chen, et al. Journal of Chinese Patent Medicine Research. 1984;(2):37.
  11. Zhou Wen Zheng, et al. Pharmacy Bulletin. 1979;14(5):202-203.
  12. Zhang Shu Chen, et al. Journal of Chinese Patent Medicine Research. 1984;(2):37.
  13. Li Yin Fang (translator). Foreign Medicine, vol. of TCM. 1984;6(1):15-18.
  14. Zhang Shu Chen, et al. Journal of Chinese Patent Medicine Research. 1984;(2):37.
  15. Li Yin Fang (translator). Foreign Medicine, vol. of TCM. 1984;6(1):15-18.
  16. Zhang Shu Chen, et al. Journal of Chinese Patent Medicine Research. 1984;(2):37.
  17. Zhou Wen Zheng, et al. Pharmacy Bulletin. 1979;14(5):202-203.
  18. Li Yin Fang (translator). Foreign Medicine, vol. of TCM. 1984;6(1):15-18.
  19. Li Yin Fang (translator). Foreign Medicine, vol. of TCM. 1984;6(1):15-18.