Jing Jie

Schizonepetae Herba, Schizonepeta

Dosage

4.5-9g.

Chemical Composition

Pulegone; Menthone; Isomenthone; Isopulegone; 1-ethoxypentane; 3-methylcyclopentanone; 3-methylcyclohexanone; Benzaldehyde; 1-octen-3-ol; 3-octanone; 3-octanol; Cymene; Limonene; Neomenthol; Menthol; Piperitone; Piperitenone; Humulene; Caryophyllene; b-pinene; 5-dimethyl-2-cyclohexen-1-one; Ethenyldimethylbezene; Cineole; Carvone; Dihydrocarvone; Verbenone; Schizonepetoside A, B, C, D, E; Schizonol; Schizonodiol; Diosmetin; Hesperidin; Hesperetin-7-O-rutinoside; Luteolin; Caffeic acid; Rosmarinic acid; Rosmarinic acid; Monomethyl ester; Schizotenuin A; 1-carboxy-2-(3,4-dihydroxyphenyl)ethyl-(E)-3[4-hydroxy-3-[(E)-1-methoxycarbonyl-2-(3,4-dihydroxyphenyl)ethenoxy]]propenoate; 3[3-[1-carboxy-2(3,4-dihydroxyphenyl)ethoxycarbonyl]-7-hydroxy-2-(3,4-dihydroxyphenyl)benzofuran-5-yl]propenoic acid; 1-carboxy-2-(3,4-dihydroxyphenyl)ethyl-(E)-3[3-[1-methoxycarbonyl-2-(3,4-dihydroxyphenyl) ethoxycarbonyl]-7-hydroxy-2(3,4-dihydroxyphenyl)-benzofuran-5-yl)propeoate. (1) , (2) , (3) , (4) , (5) , (6) , (7) , (8)

Precautions

1. Allergic reactions: swelling around the eyelids, rashes, itchiness; restlessness, chest pain.

2. Volatile oil poisoning: One case of Jing Jie volatile oil poisoning (15ml) has been reported.

Pharmacology

Analgesic and antipyretic effects

Research shows that Jing Jie can relieve pain and reduce fever. (9) , (10) , (11)

Hemostatic effects

Jing Jie's lipid-soluble extract StE has a signifcant hemostatic effect - it significantly speeds up blood clotting, thereby reducing bleeding time. (12) , (13) , (14) , (15)

Effects on intestines

At low dosages, Jing Jie extract StE excites isolated rabbit intestinal canal's smooth muscles, an effect that can be counteracted by atropine. At large dosages, however, StE has an inhibitory effect, and it counteract Bac12-induced enterospasmic contraction. (16)

Anti-oxidation effects

Jing Jie extract StE can increase the PGE content in hamsters' blood plasma, inhibit induced lipid peroxidation, and lower the MDA content in the system being induced. All effects become more pronounced as the dosage increases. (17)

Anti-inflammatory effects

To varying degrees, volatile oil of Jing Jie inhibits modeled acute and chronic inflammation in animals, indicating that it has an excellent anti-inflammatory effect. (18) , (19) , (20) , (21) , (22)

References

  1. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Techonology Press; 19983.
  2. Shi Jun (translator). Foreign Medicine, vol. of TCM. 1983;5(2):40-42.
  3. Dai Ming (translator). Foreign Medicine, vol. of TCM. 1983;5(4):39.
  4. Ye Ding Jiang, et al. TCM Bulletin. 1985;10(7):19-21.
  5. Ye Ding Jiang, et al. Journal of Nanjing College of TCM. 1985;(1)49-5.
  6. Ye Ding Jiang, et al. TCM Bulletin. 1985;10(7)19-21.
  7. Liu Ju Tao, et al. China Journal of Pharmacy. 1999;34(2):87-89.
  8. Zang You Wei, et al. China Journal of TCM. 1989;14(9):544-545.
  9. Li Shu Rong, et al. Journal of TCM Materials. 1989;12(6):37-39.
  10. Sun Shi Xi. China Journal of Medical Science. 1956;42(10):964-968.
  11. Liu Ying Quan (translator). Foreign Medicine, vol. of TCM. 1981;3(6):48-49.
  12. Ding An Wei, et al. China Journal of TCM. 1993;18(9):535-538.
  13. Ding An Wei, et al. China Journal of TCM. 1993;18(10):598-600.
  14. Ding An Wei, et al. China Journal of Medical and Pharmaceutical Sciences. 1989;4(2):110-111.
  15. Ding An Wei, et al. China Journal of TCM. 1994;19(7):412-413.
  16. Xu Hui Qi, et al. Journal of Nanjing College of TCM. 1994;10(6):25-26.
  17. Ding An Wei, et al. Journal of Nanjing University of TCM. 1998;14(5):282-283.
  18. Zeng Nan, et al. Journal of TCM Pharmacology and Clinical Application. 1998;14(6):24-26.
  19. Xie Zhong Zhi. Sichuan Journal of TCM. 1983;1(2):56.
  20. Zhu De Zi. Shandong Journal of TCM. 1989;8(1):11.
  21. Hou Xin. China Journal of TCM. 1990;15(2):54.
  22. Li Pei Zheng, et al. China Journal of Internal Medicine. 1964;12(9):893.