Mai Dong

Ophiopogonis Radix, Ophiopogon Root

Dosage

6-12g.

Chemical Composition

Naringin; Hop-21-ene; Fern-9(11)ene; Fern-7-ene; Filic-3-ene; b-sitosterol; Stigmasterol; Campesterol; Cycloardenyl acetate; Cyclomargenyl acetate; Cyclolaudenyl acetate; 9, 10-cyclolanost-25-en-3b-yl acetate; Diplopterol; Cyclolaudenol; Cyclomargenol; Cyclolaudenone; N-dotriacontanic acid; 25-en-cycloartenol; 25-en-cycloartenone; 5-stigmasten-3-ol; 5-stigmasten-3-one; Neohop-13(18)-ene. (1) , (2)

Precautions

Contraindication: Diarrhea due to insufficiency-type cold; excessive dampness; wind-cold pathogen; phlegm and cough syndrome due to cold.

Pharmacology

Anti-asthma and anti-allergic effects

In healthy guinea-pigs, Mai Dong polysaccharide can counteract bronchial contraction induced by a mixture of acetylcholine and histamine. The same effect is observed in guinea-pigs of egg white-induced allergies, inhibiting the occurrence of asthma. Mai Dong also significantly counteracts heterogeneous, passive ear allergic reactions in mice. (3)

Anti-mutational effect

Mai Dong does not cause mutation in hereditary substances. At large dosages, however, Mai Dong counteracts mutation. (4)

Anti-aging effect

Mai Dong can counteract the aging effect brought on by D-galactose. It can also decrease the body's free radical reaction, thus counteracting aging. (5)

Lowering the blood sugar level

Administered at the dosage of 40g/kg, Mai Dong can significantly lower the blood sugar level in mice of alloxan-induced diabetes; the same effect is not observed in healthy mice. (6) Mai Dong polysaccharide significantly inhibits blood sugar in both mice of experimental diabetes and healthy mice. (7)

Effects on immunologic competence

Mai Dong polysaccharide can significantly increase the weight of young mice's thymus gland and spleen, and activate the swallowing function of mice's reticuloendothelial system.

References

  1. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Techonology Press; 1998.
  2. Wang Ben Xiang (ed). Modern TCM Pharmacology. Tianjin: Science and Technology Press; 1997.
  3. Wang Ben Xiang (ed). Modern TCM Pharmacology. Tianjin: Science and Technology Press; 1997.
  4. Zhou Xu, et al. Shanxi Journal of TCM. 1999;15(1):34-35.
  5. Chen Xing Can, et al. Journal of TCM. 1998;26(1):36-37.
  6. Wan Hong Jiao, et al. China Journal of TCM Science and Technology. 1998;5(4):218-219.
  7. Qin Lu Ping, et al. Journal of Pharmacy Practice. 1999;17(3)169-171.