Niu Bang Zi

Arctii Fructus, Arctium

Dosage

6-12g.

Toxicity

Niu Bang Zi can cause tonic convulsion in frogs, mice, and rabbits: the breathing slows down first, then spontaneous activities decrease, and finally, paralysis sets in without stopping the heartbeat. (1)

Chemical Composition

Arctiin; Arctigenin; Glucose; Matairesinol; Trachelogenin; Sesquilignan AL-D, AL-F; Lappaol A-F, H; Arachic acid; Stearic acid; Palmitic acid; Linoleic acid. (2)

Pharmacology

Anti-bacterial effect

In-vitro experiments show that 100% solution of Niu Bang Zi has an inhibitory effect on Staphylococcus aureus, pneumococcus, beta streptococcus, and typhoid bacillus, and that the infusion of Niu Bang Zi inhibits various fungi. (3) , (4) , (5) , (6)

Anti-neoplastic effect

In-vitro experiments show that Niu Bang Zi extract has a 90% inhibition rate on JTC-26 (uterine cervical cancer cells). (7)

Inhibitory effect on nephritis

Experiments show that arctiin, an active component of Niu Bang Zi, has a diuretic effect. (8) Arctiin also has an inhibitory effect on PA-induced nephrosis and anti-nephroserum-induced immunonephritis in rats. (9) , (10) , (11)

Effects on the cardiovascular system

Arctiin has an anesthetic effect on isolated frog hearts. It also dilates the blood vessels of frogs’ legs and rabbits’ ears, and lowers blood pressure in rats with spontaneous hypertension. (12)

Effects on smooth and skeletal muscles

Niu Bang Zi has an inhibitory effect on the isolated rabbit uterus and intestines, and has an paralytic effect on motor nerves and skeletal muscles. (13)

Lowering blood sugar

Niu Bang Zi extract can significantly and lastingly lower blood sugar in rats, raising their tolerance for carbonhydrates. (14)

References

  1. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Techonology Press; 1998.
  2. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Techonology Press; 1998.
  3. Chinese Academy of Medical Sciences, et al. History of Chinese Materia Medica, vol. I. People's Health Press; 1984.
  4. Group of Internal Medicine, Chongqing Medical Univeristy Hospital, No. 1. Journal of Microbiology. 1960;8(1):52.
  5. Group of Virology. Institute of Pharmacy. Academy of Traditional Chinese Medicine. Journal of Modern Medicine and Pharmacology. 1973;(12):38.
  6. Cao Ren Li, et al. China Journal of Dermatology. 1957;(4):286.
  7. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Techonology Press; 1998.
  8. Liu Shou Shan (ed). Abstracts of Chinese Materia Medica Research Papers. Science and Technology Press; 1963;111.
  9. Chang-Gu-Chuan-Ya-Zi. Foreign Medicine, vol. of TCM. 1990;12(6):47.
  10. Xu Qiang, et al. China Journal of Chinese Medicine. 1990;15(2):35.
  11. Chang-Gu-Chuan-Ya-Zi. Foreign Medicine, vol. of TCM. 1991;13(2):53.
  12. Jiangsu College of Modern Medicine. Dictionary of Chinese Meteria Medica. Shanghai: People's Press; 1977.
  13. Jiangsu College of Modern Medicine. Dictionary of Chinese Meteria Medica. Shanghai: People's Press; 1977.
  14. Jiangsu College of Modern Medicine. Dictionary of Chinese Meteria Medica. Shanghai: People's Press; 1977.