Shu Di Huang

Radix Rehmanniae Preparata, Rehmannia (processed)

Dosage

9-15g.

Toxicity

LD50: 19.66 ( 2.8g/kg (mice/wine-processed herb decoction/abdominal injection). (1)

Chemical Composition

Catalpol; Rehmannin; Aucubin; Rehmannioside A, B, C, D; Leonuride; Monomelittoside; Dihydrocatalpol; Melittoside; Rehmaglutin A, D; Glutinoside; Jioglutin A, B, C; Jioglutolide; Jiofuran; Rehmapicrogenin; Trihydroxy-b-ionone; Dihydroxy-b-ionone; Aeginetic acid; Sec-hydroxyaeginetic acid; Succinic acid; 5-oxoproline; 5-hydroxymethylfuroic acid; Uracil; Uridine; Linoleic acid; Palmitic acid; Stearic acid; Arachidic acid; Pentadecanoic acid; Palmitoleic acid; Myristic acid; Nonadecanoic acid; Heneicosanoic acid; Margaric acid. (2) , (3) , (4) , (5) , (6) , (7)

Pharmacology

Enhancing immunity

Oral-feeding mice the alcohol-based extract of this herb can significantly decrease the T lymphocytes in the peripheral blood; administering by abdominal injection F108, an extract of the herb, to mice activates the abdominal macrophage, increasing their phagocytic activity. (8)

Delaying the aging process

The water decoction of the herb can significantly increase the activity of glutathione peroxidase in animals' blood serum, decrease the lipid peroxide content, and increase the activity of superoxide dismutase in the blood. (9)

Anti-hyperthyroidism

Oral-feeding hamsters the water decoction of this herb can significantly lower the concentration level of T3, and at the same time significantly increase the concentration level of T4, in the plasma, thereby significantly decreasing water intake and urine, and arresting weight loss. (10) , (11) , (12)

Affecting monoamine oxidase (MAO) activity

The water decoction of this herb can decrease the activity of monoamine oxidase in mice's cerebral mitochondria. (13)

References

  1. Materia Medica Group. Medical Vacational College of Norther Henan. Pharmacy Bulletin. 1982;17(2):114.
  2. Wang Ben Xiang. Modern TCM Pharmacology. Tianjin: Science and Technology Press; 1997.
  3. Ni Mu Yun, et al. China Journal of Materia Medica. 1989;14(3):149.
  4. Liu Zhong Yu. Materia Medica Bulletin. 1984;9(1):17.
  5. Bian Bao Lin. China Journal of Materica Medica. 1991;16(6):339.
  6. Hu Shi Lin. Genuine TCM Materia Medica. Helongjiang: Science and Technology Press; 1989.
  7. Editorial Committee. Chinese Materia Medica. Beijing: People's Medical Publishing House; 1975.
  8. Cao Zhong Liang, et al. Henan Journal of TCM. 1989;9(3):86.
  9. Yin Zhi Zhang, et al. Proceedings of the 3rd Symposium on Chinese Materia Medica and Natural Medicinal Materials (Northern and Northwestern Regions). 1988.
  10. Qu Feng Yu, et al. Heilongjiang Journal of TCM. 1998;21(5):6.
  11. Zhang Peng Xia, et al. China Journal of Gerontology. 1999;19(3):174-175.
  12. Hou Shi Liang, et al. China Journal of Materia Medica. 1992;17(5):301.
  13. Cao Cai, et al. China Journal of Gerontology. 1998;18(2):102-103.