Wu Wei Zi

Fructus Schisandrae Chinensis, Schizandra

Dosage

1.5-6g.

Toxicity

LD50: 8.75 ( 2.41g/kg (mice/herb volatile oil/oral feeding). (1)

Chemical Composition

Preschisanthrin; Schisanhenol; Kadsulactone acid; Wuweizichun A, B; Angeloylgomisin H, O, P, Q; Tigloylgomisin H; Benzoylgomisin H; Pregomisin; Meso-dihydroguaiaretic acid; Epigomisin O; Wuweizisu A, B, C; Demethylgomisin J; Deangeloylgomisin B, F; Tigloylgomisin P; Angeloylisogemisin O; Benzoylisogomisin O; Schisantherin D; Nordihydroguaiaretic acid; a-thujene; a, b-pinene; Camphene; a-phellandrene; b-terpinene; Terpinen-4-ol; a-terpineol; a-acopaene; b-elemene; Acoradiene; a, b-himachalene; Nerolidol; Furaldehyde; 2-undecanone; P-isopropylbenzoic acid; Gomisin A-J, K1-3, L1-2, M1-2, N-P, R-T. (2) , (3) , (4)

Pharmacology

Raising the white blood cell count, enhancing immunity, and counteracting oxidation

Administering this herb to mice significantly counteracts cyclophosphamide-induced decrease in white blood cells, and inhibits the thymus gland. (5) , (6) This herb also significantly counteracts CCl4 poisoning, enhances the adrenocortical function, and inhibits lipid oxidation in mice. (7) , (8) , (9) , (10)

Anti-neoplastic effect

This herb has a limited inhibitory effect on the mutagenicity of fungal extracts, indicating that it has the potential for counteracting cancer. (11)

Protecting the liver

This herb promotes bile secretion in healthy mice, and promotes liver regeneration in mice whose liver has been partially removed. (12) , (13)

Repairing free oxygen radical-caused damages

Schisanhenol, an active component of this herb, can protect free oxygen radical-caused damages to the brain and to spleen lymphocytes. (14) , (15)

Delaying the aging process

This herb promotes RNA and PAS synthesis in the testicles and ovaries, improves tissue cell metabolism, and promotes ovulation and the regeneration of reproductive cells. (16) , (17)

Anti-viral effect

Having a chemical structure similar to that of emphotericin B, this herb has an inhibitory effect on fungi similar to that of the latter, too. (18)

References

  1. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Technology Press; 1998.
  2. Li Zi Yan, et al. Journal of Chinese Materia Medica. 1996;27(1):3-4.
  3. You Zhi Peng, et al. Journal of Pharmacy. 1997;32(6):455-457.
  4. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Technology Press; 1998.
  5. Li Yan, et al. Journal of Norman Bethune Medical University. 1995;21(6):583-385.
  6. Qu Shao Chun, et al. Jilin Journal of Chinese Medicine. 1996;(2):41-42.
  7. Sui Da Yuan, et al. Journal of Norman Bethune Medical University. 1996;22(6):606-607.
  8. Xu Zhi Qi, et al. China Journal of Medicine. 1988;3(1):30-328.
  9. Wan Ji Jin, et al. Fujian Journal of TCM. 1988;19(5):79-80.
  10. Huang Yi Sen, et al. China Journal of Pharmacy and Toxicology. 1990;4(4):275-277.
  11. Ruan Cui Cai, et al. Guangxi Journal of Medicine. 1995;17(6):473-475.
  12. Gao Pu Jun, et al. Journal of Norman Bethune Medical University. 1996;22(1):23-24.
  13. Wu Bing Chun, et al. Journal of Chinese Medicine. 1987;(3):32-33.
  14. Li Li, et al. Journal of Pharmacy. 1997;32(3):178-182.
  15. Li Li, et al. Journal of Pharmacy. 1998;33(2):81-86.
  16. Peng Guo Rui, et al. Shanghai Journal of Chinese Medicine. 1989;(2):43-45.
  17. Qiu Rong, et al. Gansu Journal of Medicine. 1992;11(5):288.
  18. Zhao Xiao Yang, et al. China Journal of Dermatological Venereology. 1992;6(3):149-150.