Ze Xie

Rhizoma Alismatis, Alisma

Dosage

6-9g.

Toxicity

LD50: 0.78g/kg (mice/alcohol-based extract/IV); 1.27g/kg (mice/alcohol-based extract/abdominal injection) (1) , (2)

Chemical Composition

Alisol A, B, C; Alisol A monoacetate; Alismol; Alismoxide; Epialisol A; Tricosane; Stearic acid; Glyceryl-1-stearate; Daucosterol-6'-O-stearate; Alisol B monoacetate; Emodin; Alisol C monoacetate. (3) , (4) , (5)

Pharmacology

Diuretic effect

Taking this herb orally by healthy people increases the urine, sodium, and urea output. (6) , (7) , (8)

Effects on kidney stones

In experiments on hamsters, the water decoction of this herb significantly lowers the renal calcium content and decreases calcium oxalate crystal formation in the renal tubule, thereby inhibiting the formation of kidney stones. (9) , (10)

Enhancing immunity end anti-inflammation

Administered to mice at the dosages of 10g/kg and 20g/kg, the water decoction of this herb slows down carbon clearance, and inhibits 2, 4-chloronitrobenzene-induced contact dermatitis. (11)

Effects on the cardiovascular system

An Alcohol-based extract of the herb increases isolated rabbit heart’s coronary artery blood flow volume, has a slight inhibitory effect on miocardia, but does not affect the heartbeat rate. (12)

Lowering blood fat & anti-atherosclerosis

In experiments on hamsters, this herb significantly lowers the levels of total cholesterol and LDL-cholesterol in the serum, inhibits blood platelet aggregation and thrombosis, and enhances fibrinolysin activity. (13)

Lipotropic effect

This herb has a significant inhibitory effect on high fat feed-induced fatty liver. (14)

Promoting weight loss

Administering raw herb decoction (20g/kg) to sodium glutamate-fattened hamsters lowers their Lee index, fat indices, and serum nitroglycerine content. (15)

References

  1. Wang Ben Xiang (ed). Pharmacology of Modern Chinese Medicine. Tianjin: Science & Technology Press; 1997.
  2. Wen Hong Mei, et al. Journal of Medicine Analysis. 1998;18(6):375-377.
  3. Cai Li Ning. Journal of Natural Material Research and Development. 1996;8(1):5-9.
  4. Wang Xin Hua. Journal of Chinese Materia Medica. 1999;30(7):557-559.
  5. Qian Ben Yu. Chinese Medicine Bulletin. 1984;9(1):46.
  6. Shi Jiu Liang, et al. Haerbin Journal of Traditional Chinese Medicine. 1962;(1):60-61.
  7. Xu Wen Fu. Fujian Journal of Chinese Medicine. 1963;8(1):42-44.
  8. Deng Zu Pan, et al. China Journal of Medicine. 1961;47(1):7-11.
  9. Yi Chun Ping, et al. Journal of Tongji Medical University. 1996;25(4):321-322.
  10. Yi Chun Ping, et al. Journal of Tongji Medical University. 1997;26(2):99-101.
  11. Dai Yue, et al. China Journal of Chinese Medicine. 1991;16(10):622.
  12. Yamahara J. Journal of Foreign Medicine. 1991;6(2):86.
  13. Institute of Pharmacy. People's Experiment Hospital of Zhejiang. Chinese Materia Medica Bulletin. 1976;(7):26-30.
  14. Institute of Pharmacy. People's Experiment Hospital of Zhejiang. Chinese Materia Medica Bulletin. 1976;(7):26-30.
  15. Dai Yue, et al. Journal of Chinese Patent Medicine. 1992;14(2):28-29.