Da Qing Ye

Isatidis, Isatis Leaf

Dosage

Its decoction 10-15g, fresh leaf 30-60g or pounded juice can be orally taken.

Chemical Composition

Indigotin; Isatan B; Indirubin; D-xylo-5-hexulofuranosonic acid. (1)

Inorganic Chemicals

Fe, Ti, Mn, Zn, Cu, Co, Ni, Se, Cr, As.

Precautions

Contraindication: Spleen-yang insufficiency.

Pharmacology

Anti-endotoxin effects

In vivo and in vitro experiments show that Da Qing Ye has an inhibitory effect on Bacillus coli O111B4. In vitro experiments show that even after being diluted 64 times, 1% solution of Da Qing Ye’s chloroform-based extract still can destroy endotoxin. In vivo experiments show that Da Qing Ye-treated endoxin (40EU/kg) loses its typical heat-inducing activity in rabbits. Da Qing Ye can also inhibit the formation of micro-thrombus in the glomerulus of rabbits with endotoxic disseminated intravascular coagulation (DIC). (2) , (3)

Inhibiting pathogenic microorganisms

Da Qing Ye has a moderate inhibitory effect on Staphylococcus aureus, streptococcus A, Diplococcus meningitidis, streptococcus pneumoniae, catarrhalis, Typhoid bacillus, Bacillus coli, influenza bacillus, Bacillus diphtheriae and Bacillus dysenteriae. It also has an inhibitory effect on encephalitis B, parotitis, and influenza. (4) , (5) , (6)

Anti-inflammatory effects

In experiments on croton oil-induced ear swelling in mice, Da Qing Ye solution was administered to the subjects via stomach perfusion, 1ml each time, twice a day, for 3 consecutive days. The results show that Da Qing Ye has a significant anti-inflammatory effect. (7)

Resisting free radicals of oxygen

Experiments show that administered to mice by intravenous injection, Da Qing Ye can significantly increase the super-oxide dismutase (SOD) level, and significantly lower the lipid peroxide (LPO) level in the subjects. And studies of Da Qing Ye extract’s effect of resisting active oxygen using H2O2-CTMAB-luminol luminous system show that the herb has a dose-dependent effect of resisting H2O2. (8) , (9)

Enhancing immunity

Experiments show that administered to mice by abdominal injection, Da Qing Ye can significantly strengthen the phagocytic function of the subjects’ abdominal macrophages, significantly increasing the phagocytic rate and the phagocytic index. Administered to mice by intragastric perfusion, Da Qing Ye increases the content of serum lysozyme. (10)

References

  1. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Technology Press; 1998.
  2. Liu Yun Hai, et al. Experiments on Da Qing Ye’s anti-endotoxic effects. Journal of Traditional Chinese Medicine Material. 1994;17(6):36-37.
  3. Li Ming Zheng, et al. The pharmadynamics of Re Du Qing Injection. China Journal of Experimental Recipes. 1996;2(6):24-30.
  4. Health and Epidemic Prevention Station of Lingling. 287 herbs’ antibacterial effects. Hunan Journal of Medicine and Herbs. 1975;2(1):46.
  5. Chen Guo Qing, et al. The mechanism by which Wan Nian Qing and other Fujian folk herbs treat diphtheria. Fujian Journal of Chinese Medicine. 1964;(2):33.
  6. Wang Yu Sheng, et al. TCM Pharmacology and Application, 1st ed. Beijing: People’s Health Press; 1983.
  7. Li Ming Zheng, et al. The pharmadynamics of Re Du Qing Injection. China Journal of Experimental Recipes. 1996;2(6):24-30.
  8. Li Ming Zheng, et al. The pharmadynamics of Re Du Qing Injection. China Journal of Experimental Recipes. 1996;2(6):24-30.
  9. Long Sheng Jing, et al. 17 antipyretic herbs’ effect of resisting active oxygen. Journal of Chinese Materia Medica. 1999;30(1):40-43.
  10. Li Ming Zheng, et al. The pharmadynamics of Re Du Qing Injection. China Journal of Experimental Recipes. 1996;2(6):24-30.