Bai Fan

Alumen, Alum

Dosage

It is powdered with 1-3g.

Toxicity

When 8% Ban Fan injection was administered to the perirectal abscess of rabbits and dogs (at 2ml/kg), there occurred local hemorrhagic coagulability necrosis. Continued use resulted in scars of collagenous fiber in the surrounding areas, which caused the following conditions: anuresis, urinary incontinence, diarrhea, dysporia, edema of anus, perineum and testis, even necrosis of tissue around anus, rectum fistula and advanced stage of rectostenosis. (1) Fed to mice at 0.25g/kg or 1g/kg for 0.5, 2, and 3 months, Bai Fan can induce alteration to the intestinal flora. As a result, the quantity of lactobacillus decrease noticeably and the quantity of pathogenic colibacillus increases significantly. The longer the time Bai Fan is administered, the greater its impact on the in

Chemical Composition

KAl3(SO4)2(OH)6; K2O; Al2O3; SO3; H2O; KAl(SO4)2·12H2O. (2)

Precautions

Overdose of Bai Fan can cause vomiting. Patients of a weak constitution and deficient stomach functions should use with caution.

Pharmacology

Antibacterial effects

In vitro experiments show that Bai Fan has inhibitory effects on Staphylococcus aureus, Hemolytic streptococcus, pneumococcus, Bacillus proteus, colibacillus, Pseudomonas aeruginosa, Shigella flexneri, Shigella shegae, Typhoid bacillus, Salmonella paratyphi A, Bacillus diphtheriae, and Anthrax bacillus. The inhibitory effects on Brucella bovis, Bacillus pertussis, and meningococcus are less pronounced than on the other bacteria. In high concentrations, it can also inhibit Mycobacterium tuberculosis hominis and Mycobacterium tuberculosis bovis. It significantly inhibits variant streptococcus, nucleic acid bacillus, Bacillus perfringens, and other anaerobic bacteria, such as various oral bacteria. It has mild inhibitory effects on Bacillus tetani and facultative anaerobe, and gonococcus. It also has significant inhibitory effects on Microsporum, red Trichophyton prupureatum and Candida albicans, etc. (3) , (4) , (5) , (6) , (7) , (8)

Inhibiting Trichomonas vaginalis

Bai Fan can significantly inhibit Trichomonas vaginalis in vitro. (9)

Astrigent effects

Bai Fan solution can induce immediate sedimentation in in vitro serum, indicating its strong protein coagulation effect. It can be applied clinically for hemostatic, anhidrotic, and antidiarrheal effects. (10)

Anti-convulsant effects

Administered to mice, Bai Fan can reduce the occurrence rate of convulsion caused by electricity, dimefline, and nitric strychnine, and can lengthen the latency of dimefline-induced convulsion. (11)

Inhibiting early pregnancy

Administered to female mice by stomach perfusion at 20mg/10g/day, Bai Fan has an anti-fertility rate of 74%, and an anti-early pregnancy rate of 82%. One study treated young female mice with Bai Fan for six consecutive days (10mg/kg/day). In the second three-day period, the subjects were also treated with estradiol benzoate (20mg/mouse/day, by intramuscular injection). The results showed that Bain Fan can counteract estrogen-induced uterus weight increase. (12) , (13)

References

  1. External Medicine Lab, Guananmenwai Hospital. Treating proctoptosis with Bai Fan. Traditional Chinese Medicine Research Reference. 1974;(5):33.
  2. The Institute of Pharmacy. Chinese Academy of Medical Sciences. Annals of Chinese Herb, vol 4. Beijing: People’s Health Press; 1961.
  3. Microbiology Group. Henan Medical College. The antibacterial effects of 104 Chinese herbs. Journal of Henan Medical College. 1960;(7):33.
  4. Microbiology Group. Shandong Medical College. Journal of Shandong Medical College. 1959;(8):42.
  5. Chen Bing Tong. The antibacterial effects of 330 commonly used Chinese herbs. China Journal of Medicine. 1964;50(8):524.
  6. Mu Zhi Ping, et al. The in vitro antibacterial effects of 17 Chinese herbs. China Journal of Tuberculosis. 1959;7(1):51.
  7. Zi Jian Wen, et al. The antifungal effect of Bai Fan. Yunan Journal of TCM. 1990;11(3):26.
  8. Cao Song Nian, et al. The antifungal effects of Chinese single herbs and formulas. China Journal of Medicine. 1962;48(12):781.
  9. Parasite Research Group. The effects of 57 Chinese herbs on Trichomonas vaginalis. Journal of Henan College of Medicine. 1960;(7):23.
  10. External Medicine, Shaoxing No. 2 Hospital. Treating 80 cases of internal hemorrhoids with Bai Fan. China Journal of External Medicine. 1958;6(10):1167.
  11. Wen Lei, et al. The anticonvulsive effect of Mie Nang Ling. Journal of New Chinese Medicine, and Clinical Pharmacology. 1999;10(1):24-26.
  12. Li Shu Lian, et al. The anti-early pregnancy effect of Bai Fan. Traditional Chinese Medicine News. 1995;(5):14.
  13. Li Shu Lian, et al. Anti-implantation and anti-early pregnancy Chinese herbs. Journal of Traditional Chinese Medicine and Herbs. 1995;12(6):21-22.