Fu Zi

Aconiti Lateralis Preparata Radix, Processed Aconite

Dosage

3~9g, decocted in water, or processed into powder for oral administration; 18~30g for recuperating depleted yang and rescuing the patient from collapse.

Toxicity

LD50 (mice/decoction of processed Fu Zi): 17.42 ± 1.024g/kg (gastrolavage); 3.516 ± 0.409g/kg (IV injection).

Chemical Composition

Mesaconitine; Hypaconitine; Higenamine; Coryneinechloride; Isodelphinine; Aconitine; Neoline; Fuziline; Salsolinol; Karakoline; Beiwutine; Racemic demethylcoclaurine; Benzoylmesaconine. (1)

Precautions

    Contraindications: hyperactivity of yang due to yin deficiency, heat syndromes with pseudo-cold symptoms, and pregnancy. Refrain from alcohol use when taking this herb. This herb is incompatible with Ban Xia, Gua Lou, Bai Lian, Bai Ji, and Bei Mu. Improper use may lead to herb poisoning.

Pharmacology

Affecting the diaphragmatic function in rabbits

The effect of Fu Zi decoction on rabbits’ diaphragmatic function as recorded by diaphragmatic spontaneous discharge integral (SDI) value and diaphragmatic myogram (DMG) are as follows: 1) Fu Zi decoction can increase the peak value and the slope of the SDI curve, and the DMG high frequency to low frequency ratio; 2) Intraperitoneal injection of Fu Zi decoction (200mg/kg) promotes recovery from diaphragmatic fatigue; and 3) Fu Zi affects the diaphragmatic function by activating the b-adrenergic receptors of diaphragmatic muscles. (2)

Anti-oxidation effects

Alcohol-based extract of Fu Zi has a rather pronounced inhibitory effect on linoleic acid-induced air oxidation. It can also enhance the activity of blood glutathione peroxidase and catalase in mice. Fu Zi is a natural antioxidant, which forms the basis for its modern pharmacology. (3)

References

  1. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Technology Press; 1998.
  2. Han Yong Qin, et al. Liaoning Journal of Traditional Chinese Medicine. 1998;25(10):492-494.
  3. Zhang Qi Lan, et al. Journal of Chinese Materia Medica. 1996;27(9):544-546.