Xuan Shen

Radix Scrophulariae Ningpoensis, Scrophularia

Dosage

9-15g.

Toxicity

LD50 (mice/herb decoction/abdominal injection): 15.99-19.81g/kg. (1)

Chemical Composition

Scrophularin; Harpagoside; Aucubin; Ningpogenin; Aingpogoside A, B; Asparagine; 6-O-methylcatalpol; 3, 4’-dimethylangoroside A; 8-(O-methyl-p-coumaroyl)harpagide; 7-hydroxy-9-hydroxymethyl-3-oxo-bicyclo [4.3.0]-8-nonene. (2) , (3) , (4) , (5)

Pharmacology

Effects on the cardiovascular system

Experiments show that the infusion of this herb lowers blood pressure; the solution of this herb’s alcohol-based extract significantly increases the coronary artery volume of the isolated rabbit heart, moderately inhibits the heartbeat rate and myocardial contraction, significantly improves healthy mice’s endurance of oxygen-deprivation. (6) , (7)

Antibacterial effect

In-vitro experiments show that this herb counteracts a number of bacteria, including Staphylococcus aureus, Bacillus diphtheriae, typhoid bacillus, beta hemolytic streptococcus, Pseudomonas aeruginosa, Shegella flexneri, Bacillus coli, Trichophyton mentagrophytes, Epidermophyton floccosum, and Nocardia asteroides. (8) , (9) , (10) , (11) , (12)

Effects on the body’s blood sugar concentration

There have been reports that the decoction of this herb raises the blood sugar concentration, and this effect peaks three hours after treatment. (13)

References

  1. Chen Shao Ying, et al. Fujian Journal of Chinese Medicine. 1986;17(4):57.
  2. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Techonology Press; 1998.
  3. Wang Ben Xiang (ed). Pharmacology of Modern Chinese Medicine. Tianjin: Science & Technology Press; 1997.
  4. Editorial Committee. All-China Materia Medica. Beijing: People’s Medical Publishing House; 1975.
  5. Lin Qi Shou. Chemical Composition of Materia Medica. Beijing: Science Press; 1977.
  6. Zhang Bao Heng. Journal of Beijing Medical College. 1959;(1):59.
  7. Gong Wei Gui, et al. Zhejiang Journal of Medicine. 1981;3(1):11.
  8. Chen Shao Ying, et al. Fujian Journal of Chinese Medicine. 1986;17(4):57.
  9. Zheng Qi Yin, et al. Pharmacy Bulletin. 1960;8(2):57.
  10. Cao Ren Liu, et al. China Journal of Dermatology. 1957;5(4):286.
  11. Antibacterial Group. Institute of Chinese Materia Medica. China Medical Academy. Pharmacy Bulletin. 1960;8(2):29.
  12. Zheng Wu Fei, et al. China Journal of Medicine. 1952;38(4):315.
  13. Tang Ru Yu, et al. China Journal of Medicine. 1958;44(2):150.