Huo Ma Ren

Fructus Cannabis, Linum

Dosage

3-10g boiling in water or in the form of pill or powder. 5:1 concentrated extract: 2-3 grams/day.

Toxicity

It should be used with caution by patients suffering from diarrhea, impotence, seminal emission, gynecological diseases due to spleen and kidney insufficiencies. Reported poisoning signs include confusion in speech, blurred vision, incontinence in urination and defecation etc. (1) , (2)

Chemical Composition

Cannabinol; Trigonelline; L(+)-isoleucine betaine; Zeatin; Linoleic acid; Linolenic acid; Oleic acid; Tetradecenic acid; Hexadecenoic acid; Heptadecenoic acid; Octadecenic acid; Octadecamonoenoic acid; Linoleic acid; Linolenic acid; Vitamin E1, B1, B2; Lecithin; Muscarin; Choline; Steroids; Glucuronic acid; Edestinase; Phytin; Cannabisin A, B, C; Phenyl-dihydronaphthalene-lignanoxamides. (3) , (4) , (5) , (6) , (7)

Pharmacology

Lowering lipid levels and counteracting atherosclerosis

Huo Ma Ren oil can lower the levels of total serum cholesterol, triglyceride, low-density lipoprotein (LDL), and lipid peroxide in rats. (8) It can also lower the levels of total glycerides and low-density lipoprotein cholesterol, and raises the level of high-density lipoprotein (HDL) cholesterol level in male Korean quails, thereby lowering the atherosclerosis index, lessening the pathological changes in the endothelial and smooth muscle cells of the artery wall, and regulating lipid metabolism. (9)

Analgesic, anti-inflammatory, and anti-thrombotic effects

When administered to mice by intraperitoneal infusion at 5 and 15g/kg, Huo Ma Ren’s alcohol-based extract can inhibit xylol-induced ear lobe swelling, carrageenin-induced foot pad edema, and acetic acid-induced increase in peritoneal capillary permeability. The same treatment can also reduce the incidence of acetic acid-induced body twisting in mice, and prolong thrombus formation time and coagulation time in rats under electric stimulation to the carotid artery. (10)

References

  1. Wu De Hui. One case of Ying Su Guo and Huo Ma Ren poisoning. Jiangxi Journal of TCM. 1991;12(10):17.
  2. Li Feng Cun. A clinical analysis of 122 cases of Huo Ma Ren oil poisoning. Shanxi Journal of Medicine. 1978;(6):33-35.
  3. Ling Nian, et al. Determination of delta-tetrahyde cannabinol in Da Ma. Journal of Chinese Patented Medicine Research. 1958;(8):29-30.
  4. Editorial Committee of Chinese Materia Medica, State Drug Administration of China. Chinese Materia Medica. Shanghai Science and Technology Press. 1998.
  5. Ma Ai Hua, et al. Separation and quantity determination of fatty acids in 10 medicinal fruits. Journal of Shizhen Medicinal Material Research. 1998;9(1):53.
  6. Wang Ben Xiang (ed). Modern TCM Pharmacology. Tianjin Science and Technology Press, 1997.
  7. Mu Shen Yuan Yan. Chemical composition of Ma Zi Ren (2). Foreign Medicine (TCM vol.). 1993;(4):43.
  8. Ren Han Yang, et al. Huo Ma Ren oil’s effect in lowering cholesterol and counteracting lipid peroxide. China Journal of TCM Science and Technology. 1997;4(4):200.
  9. Zhang Ming Fa, et al. Huo Ma Ren’s analgesic, anti-inflammatory, and anti-thrombotic effects. Journal of Practical TCM. 1999;13(1):13-15.