Protective effects of echinacoside on carbon tetrachloride-induced hepatotoxicity in rats.

Author

Wu, Y., Li, L., Wen, T., Li, Y. Q.

Journal

Toxicology

Volume

232

Issue ID

1-2

Page

50-6

Date

2007 Mar 22

Keyword

Alanine Transaminase/blood
 Animals
 Apoptosis/drug effects
 Aspartate Aminotransferases/blood
 Carbon Tetrachloride Poisoning/*drug therapy/metabolism/pathology/prevention &
   control
 Electron Spin Resonance Spectroscopy
 Glutathione/metabolism
 Glycosides/*pharmacology
 Histocytochemistry
 In Situ Nick-End Labeling
 Liver/drug effects/enzymology/pathology
 Liver Diseases/*chemically induced/*drug therapy/metabolism/prevention & control
 Male
 Malondialdehyde/metabolism
 Random Allocation
 Rats
 Rats, Sprague-Dawley
 Reactive Oxygen Species/metabolism
 Superoxide Dismutase/metabolism
EDAT- 2007/01/16 09:00

Abstract

RThe aim of this study was to investigate the possible protective effects of echinacoside, one of the phenylethanoids isolated from the stems of Cistanches salsa, a Chinese herbal medicine, on the free radical damage of liver caused by carbon tetrachloride in rats. Treatment of rats with carbon tetrachloride produced severe liver injury, as demonstrated by dramatic elevation of serum ALT, AST levels and typical histopathological changes including hepatocyte necrosis or apoptosis, haemorrhage, fatty degeneration, etc. In addition, carbon tetrachloride administration caused oxidative stress in rats, as evidenced by increased reactive oxygen species (ROS) production and MDA

Language

eng