Ancient Concepts: Modern Pharmacogenomics

Author

PROF. BHUSHAN PATWARDHAN
Bushan Patwardhan1 ,Kalpana Joshi2
1Interdisciplinary School of Health Sciences, University of Pune, Pune
2Department of Biotechnology, Sinhagad Institute, Pune.

Language

English

Title

Ancient Concepts: Modern Pharmacogenomics

Proceeding

7th INTRACOM – 2nd ICBWI 2009

Date

23rd-26th July 2009

Place Held

PWTC, Kuala Lumpur

Abstract

Pharmacogenomic is study of genetic basis of inter-individual differences in drug metabolism. Traditional Indian medicine - Ayurveda classifies the human population into three major constituents or Prakriti known as Vata, Pitta, Kapha types. This classification is based on over 100 attributes related to differences in physical, physiological and psychological characters; however, their homologous relation to human genetic structure needs to be studied for validation.  Earlier, we have demonstrated a proof of concept in favor of genetic basis to Prakriti. Subsequently, detailed studies on Ayurveda led us to hypothesize that person with Pitta Prakriti are fast metabolizer while those of Kapha Prakriti are slow metabolizer. We relied on Drug Metabolizing Enzyme (DME) polymorphism and further hypothesized that different Prakriti may have different drug metabolism rate. We observed interesting correlation between CYP2C19 genotype and Prakriti distinguished by fast and slow metabolism as one of the major differentiating characteristic. Thus, ancient concept of classifying human populations are likely to have significant impact on phenotype – genotype correlation, drug discovery, modern pharmacogenomic and personalized medicine.

Keywords

Modern Pharmacogenomics

Session

Plenary 8

Topic

Not Available