The Potentiality of Bonsai Plant Products as Cancer Chemopreventive Agents

Author

DR MD AZMAN PKM SEENI MOHAMED
Azman Seeni1, Ridhwan Abdul Wahab1,2 , Muhammad Zuhaili Nor Yahya1 and Mohammad Razak Hamdan3
1School of Dental Sciences, Healthy Campus, Universiti Sains Malaysia, Kelantan
2Dept of Basic Health Sciences, Kuliyyah of Allied Health Sciences, International Islamic University, Pahang.
3 Centre of Drug Research, Universiti Sains Malaysia, Penang.

Language

English

Title

The Potentiality of Bonsai Plant Products as Cancer Chemopreventive Agents

Proceeding

7th INTRACOM – 2nd ICBWI 2009

Date

24th July 2009

Place Held

PWTC, Kuala Lumpur

Abstract

It is estimated there are around 8,100 plant species in the Malaysian rain  forests, with 10% of them reported to have some medicinal value. However, to date in Malaysia not much investigation been done on chemopreventive activities from the local plants extract and  therefore, this background leads to the premise that our local plants such as Streblus asper could have greater potential for the chemoprevention activities.Streblus asper is well known as an expensive bonsai plant which is indigenous to tropical countries such as Malaysia, Thailand, Sri Lanka and India. It is used traditionally in leprosy, piles, diarrhea, dysentery, elephantiasis and cancer. It finds place in Ayurvedic Pharmacopoeia of India and also been described in some monographs, but none have reported its activity as chemopreventive agents and the molecular mechanism of its ‘anti-cancer’ activity. Here in this preliminary study, we will show the effect of the Streblus asper root extracts ( from Tapak Nan Enterprise) on osteosarcoma cells. The extracts which did not having any heavy metals compound such as mercury and cadmium and with less arsenic (0.02 ppm) and plumbum (0.07 ppm) showing potential anti-cancer activities on osteosarcoma cells by suppressing the cells proliferation and differentiation. Our HPLC profiling analysis also revealed antioxidants compounds exist in the Streblus asper root extracts such as caffeic acid which has been shown to act as a carcinogenic inhibitor. In this talk, we also will show its effect on normal fibroblast such as osteoblast, human gingiva fibroblast and elucidate its cytotoxicity effects. This study is just a preliminary study as to identify its pharmacological properties on carcinogenesis and further investigation is still on-going to develop it as ‘mouth-wash product’.

Keywords

Streblus asper, Bonsai plant

Session

Symposium 2C (ICBWI

Topic

Cosmeceutical/ Function/ Bioprocess