Zizyphus Spina-Christi Protects against Induced Liver Fibrosis

Author

ASSOCIATE PROF DR AMR AMIN
Zizyphus spina-christi protects against  induced-liver fibrosis
Amr Amin1†, Doaa Mahmoud Ghoneim2
1Biology Department, College of Science, UAE University, 2Physics Department, College of Science, UAE University
†Correspondence: This email address is being protected from spambots. You need JavaScript enabled to view it.

Language

English

Title

Zizyphus spina-christi protects against induced liver fibrosis

Proceeding

7th INTRACOM – 2nd ICBWI 2009

Date

24th July 2009

Place Held

PWTC, Kuala Lumpur

Abstract

The study of hepatic fibrosis, in response to chronic liver injury, has been receiving an escalating attention in the past two decades. The aim of the study was to examine the effects of the seeds water extract of Zizyphus spina-christi (L.) (ZSC) on carbon tetrachloride (CCl4)-induced hepatic fibrosis. ZSC extract was daily intragastrically administered [alone (control group) or along with CCl4 (protected groups)] at 0.125, 0.250 and 0.350 g/kg b.wt. for 8 weeks.  Histo-pathological, biochemical and histology texture analyses revealed that ZSC significantly impede the progression of hepatic fibrosis. ZSC resulted in a significant amelioration of liver injury judged by the reduced activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Oral administration of ZSC has also restored normal levels of malondialdehyde (MDA; an index of oxidative stress-mediated lipid peroxidation) and retained control activities of endogenous antioxidants such as superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH). Furthermore, ZSC reduced the expression of alpha-smooth muscle actin (α-SMA) and the deposition of types I and III collagen in rats injured by treatment with CCl4. These results demonstrate that administration of EGCG may be useful in the treatment and prevention of hepatic fibrosis.

Keywords

Zizyphus spina-christi (L.), Liver fibrosis

Session

Symposium 4B (ICBWI)

Topic

Biomolecule Discovery