Potential Control of Malaria using Bioengineered maize pollen expressing TMOF and Bti toxins; A Sim

Author

PROF DOV BOROVSKY
Dov Borovsky1
1University of Florida, IFAS, Florida Medical Entomology Laboratory, 200 9th St SE,  Vero Beach, FL 32962

Language

English

Title

Potential  Control of Malaria using Bioengineered maize pollen expressing TMOF and Bti toxins; A Simple Holistic Approach

Proceeding

7th INTRACOM – 2nd ICBWI 2009

Date

25th July 2009

Place Held

PWTC, Kuala Lumpur

Abstract

Female mosquito transmits important diseases to humans including yellow fever, dengue, encephalitis and malaria.  These diseases cause human suffering, economic burden and death all over the globe.  A decapeptide hormone (Tryspin Modulating Oostatic Hormone-TMOF) that isolated from the ovaries of female mosquitoes in my laboratory has been genetically engineered and expressed on the coat protein of Tobacco Mosaic Virus, by chlorella, yeast and alfalfa.  The hormone stops the digestion of food in the larval gut causing anorexia and death.  TMOF synergizes with Bacillus thuringiensis israelenis (Bti) toxins increasing the efficiency of Bti many fold when used together with TMOF to control mosquito larvae.  Earlier reports from the laboratory of Professor Andrew Spielman of Harvard showed that maize pollen is used by mosquito larvae in sub-Saharan Africa as the main food source.  A novel method will be presented in which maize pollen that has been genetically engineered to express Bti toxins and TMOF can efficiently and selectively be used to control malaria transmitting mosquito larvae in Africa and beyond.

Keywords

Malaria, TMOF, Bti toxins

Session

Symposium 4C (ICBWI)

Topic

Health Promotion & Wellness Technology/ Bioprocess, Biofactory & Biobusiness